Comparative survival analysis of immunomodulatory therapy for coronavirus disease 2019 cytokine storm

S Narain, DG Stefanov, AS Chau, AG Weber, G Marder… - Chest, 2021 - Elsevier
Background Cytokine storm is a marker of coronavirus disease 2019 (COVID-19) illness
severity and increased mortality. Immunomodulatory treatments have been repurposed to …

Potential treatments for COVID-19 related cytokine storm-beyond corticosteroids

Y Miao, L Fan, JY Li - Frontiers in immunology, 2020 - frontiersin.org
CONCLUSION Although we admit that supportive care and antiviral therapy remain the
mainstay for treating patients with COVID-19, we recommend that treatments for controlling …

Profiling COVID-19 pneumonia progressing into the cytokine storm syndrome: results from a single Italian Centre study on tocilizumab versus standard of care

L Quartuccio, A Sonaglia, D McGonagle… - Journal of Clinical …, 2020 - Elsevier
Objective Approximately 5% of patients with coronavirus disease 2019 (COVID-19) develop
a life-threatening pneumonia that often occurs in the setting of increased inflammation or …

Role for anti-cytokine therapies in severe coronavirus disease 2019

LF Buckley, GF Wohlford, C Ting… - Critical care …, 2020 - journals.lww.com
Objectives: The causative agent for coronavirus disease 2019, severe acute respiratory
syndrome coronavirus 2, appears exceptional in its virulence and immunopathology. In …

[HTML][HTML] Hazards of the cytokine storm and cytokine-targeted therapy in patients with COVID-19

M Quirch, J Lee, S Rehman - Journal of medical Internet research, 2020 - jmir.org
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
challenged medicine and health care on a global scale. Its impact and frightening mortality …

[HTML][HTML] Early identification of COVID-19 cytokine storm and treatment with anakinra or tocilizumab

A Langer-Gould, JB Smith, EG Gonzales… - International Journal of …, 2020 - Elsevier
Objective To examine outcomes among patients who were treated with the targeted anti-
cytokine agents, anakinra or tocilizumab, for COVID-19-related cytokine storm (COVID19 …

Historically controlled comparison of glucocorticoids with or without tocilizumab versus supportive care only in patients with COVID-19-associated cytokine storm …

S Ramiro, RLM Mostard, C Magro-Checa… - Annals of the …, 2020 - ard.bmj.com
Objectives To prospectively investigate in patients with severe COVID-19-associated
cytokine storm syndrome (CSS) whether an intensive course of glucocorticoids with or …

Deciphering the COVID‐19 cytokine storm: systematic review and meta‐analysis

R Mulchandani, T Lyngdoh… - European journal of …, 2021 - Wiley Online Library
Introduction The coronavirus pandemic has affected more than 20 million people so far.
Elevated cytokines and suppressed immune responses have been hypothesized to set off a …

Circulating levels of interleukin-6 and interleukin-10, but not tumor necrosis factor-alpha, as potential biomarkers of severity and mortality for COVID-19: systematic …

W Udomsinprasert, J Jittikoon… - Journal of clinical …, 2021 - Springer
Purpose Cytokine storm, an uncontrolled overproduction of inflammatory cytokines
contributing to an aberrant systemic inflammatory response, is a major pathological feature …

[PDF][PDF] Cytokine-targeted therapy in severely ill COVID-19 patients: options and cautions

M Rahmati, MA Moosavi - mortality, 2020 - researchgate.net
Dear Editor, Coronavirus disease 2019 (COVID-19) is an infectious disease caused by
severe acute respiratory syndrome coronavirus 2 (SARS‐CoV-2) with the symptoms …