Enhancing predictions of antimicrobial resistance of pathogens by expanding the potential resistance gene repertoire using a pan-genome-based feature selection …

MR Yang, YW Wu - BMC bioinformatics, 2022 - Springer
Background Predicting which pathogens might exhibit antimicrobial resistance (AMR) based
on genomics data is one of the promising ways to swiftly and precisely identify AMR …

Using bacterial pan-genome-based feature selection approach to improve the prediction of minimum inhibitory concentration (MIC)

MR Yang, SF Su, YW Wu - Frontiers in Genetics, 2023 - frontiersin.org
Background: Predicting the resistance profiles of antimicrobial resistance (AMR) pathogens
is becoming more and more important in treating infectious diseases. Various attempts have …

A pan-genome-based machine learning approach for predicting antimicrobial resistance activities of the Escherichia coli strains

HL Her, YW Wu - Bioinformatics, 2018 - academic.oup.com
Motivation Antimicrobial resistance (AMR) is becoming a huge problem in both developed
and developing countries, and identifying strains resistant or susceptible to certain …

[HTML][HTML] Unitig-centered pan-genome machine learning approach for predicting antibiotic resistance and discovering novel resistance genes in bacterial strains

DT Do, MR Yang, TNS Vo, NQK Le, YW Wu - Computational and Structural …, 2024 - Elsevier
In current genomic research, the widely used methods for predicting antimicrobial resistance
(AMR) often rely on prior knowledge of known AMR genes or reference genomes. However …

[HTML][HTML] A Cross-Validated Feature Selection (CVFS) approach for extracting the most parsimonious feature sets and discovering potential antimicrobial resistance …

MR Yang, YW Wu - Computational and Structural Biotechnology Journal, 2023 - Elsevier
Understanding genes and their underlying mechanisms is critical in deciphering how
antimicrobial-resistant (AMR) bacteria withstand detrimental effects of antibiotic drugs. At the …

Parmap: A pan-genome-based computational framework for predicting antimicrobial resistance

X Li, J Lin, Y Hu, J Zhou - Frontiers in microbiology, 2020 - frontiersin.org
Antimicrobial resistance (AMR) has emerged as one of the most urgent global threats to
public health. Accurate detection of AMR phenotypes is critical for reducing the spread of …

A machine learning framework to predict antibiotic resistance traits and yet unknown genes underlying resistance to specific antibiotics in bacterial strains

J Sunuwar, RK Azad - Briefings in Bioinformatics, 2021 - academic.oup.com
Recently, the frequency of observing bacterial strains without known genetic components
underlying phenotypic resistance to antibiotics has increased. There are several strains of …

[HTML][HTML] PanKA: Leveraging population pangenome to predict antibiotic resistance

SH Nguyen, DQ Le, TT Nguyen, CH Nguyen, TH Ho… - Iscience, 2024 - cell.com
Machine learning has the potential to be a powerful tool in the fight against antimicrobial
resistance (AMR), a critical global health issue. Machine learning can identify resistance …

Antimicrobial resistance prediction for gram-negative bacteria via game theory-based feature evaluation

AS Chowdhury, DR Call, SL Broschat - Scientific reports, 2019 - nature.com
The increasing prevalence of antimicrobial-resistant bacteria drives the need for advanced
methods to identify antimicrobial-resistance (AMR) genes in bacterial pathogens. With the …

Predicting antimicrobial resistance using conserved genes

M Nguyen, R Olson, M Shukla… - PLoS computational …, 2020 - journals.plos.org
A growing number of studies are using machine learning models to accurately predict
antimicrobial resistance (AMR) phenotypes from bacterial sequence data. Although these …