Blood–brain barrier (BBB) dysfunction underlies the pathogenesis of many neurological
diseases. Platelet-derived growth factor receptor-alpha (PDGFRα) induces hemorrhagic …

Although platelet-derived growth factor receptor beta (PDGFR-β) mediates the recruitment of
vascular pericytes into ischemic lesion to restore the blood-brain barrier (BBB) dysfunction …

The neuroprotective agents and induction of endogenous neurogenesis remain to be the
urgent issues to be established for the care of cerebral stroke. Platelet-derived growth factor …

Although platelet-derived growth factors (PDGFs) and receptors (PDGFRs) are abundantly
expressed in the central nervous system, their functions largely remain elusive. We …

Abstract Treatment of acute ischemic stroke with the thrombolytic tissue plasminogen
activator (tPA) can significantly improve neurological outcomes; however, thrombolytic …

During cerebral ischemia, angiogenesis occurs inside and around the infarcted area. The
growth of new blood vessels may contribute to a better outcome after stroke due to …

Objective: Perihematomal edema results from disruption of the blood‐brain barrier (BBB) by
key mediators, such as thrombin, following intracerebral hemorrhage (ICH). Platelet‐derived …

Platelet derived growth factor (PDGF)-B plays a neuroprotective role in brain damages,
including ischemic stroke. It has been suggested recently that PDGF receptor β (PDGFRβ) …

Thrombolytic treatment of ischemic stroke with tissue plasminogen activator (tPA) is
markedly limited owing to concerns about hemorrhagic complications and the requirement …

Central nervous system (CNS) pericytes have been recognized as an indispensable
component of the neurovascular unit. The expression of platelet-derived growth factor …