Nicotinic cholinergic system and COVID-19: In silico identification of interactions between α7 nicotinic acetylcholine receptor and the cryptic epitopes of SARS-Co-V …

G Lagoumintzis, CT Chasapis, N Alexandris… - Food and Chemical …, 2021 - Elsevier
SARS-CoV-2 is the coronavirus that originated in Wuhan in December 2019 and has spread
globally. Studies have shown that smokers are less likely to be diagnosed with or be …

[HTML][HTML] Nicotinic cholinergic system and COVID-19: in silico identification of an interaction between SARS-CoV-2 and nicotinic receptors with potential therapeutic …

K Farsalinos, E Eliopoulos, DD Leonidas… - International journal of …, 2020 - mdpi.com
While SARS-CoV-2 uses angiotensin converting enzyme 2 (ACE2) as the receptor for cell
entry, it is important to examine other potential interactions between the virus and other cell …

[HTML][HTML] Nicotinic cholinergic system and COVID-19: In silico evaluation of nicotinic acetylcholine receptor agonists as potential therapeutic interventions

N Alexandris, G Lagoumintzis, CT Chasapis… - Toxicology reports, 2021 - Elsevier
SARS-CoV-2 infection was announced as a pandemic in March 2020. Since then, several
scientists have focused on the low prevalence of smokers among hospitalized COVID-19 …

[PDF][PDF] A potential interaction between the SARS-CoV-2 spike protein and nicotinic acetylcholine receptors

ASF Oliveira, AA Ibarra, I Bermudez, L Casalino… - Biophysical journal, 2021 - cell.com
Changeux et al.(Changeux et al. CR Biol. 343: 33–39.) recently suggested that the SARS-
CoV-2 spike protein may interact with nicotinic acetylcholine receptors (nAChRs) and that …

[HTML][HTML] The SARS-CoV-2 virus and the cholinergic system: spike protein interaction with human nicotinic acetylcholine receptors and the nicotinic agonist varenicline

EC Carlson, M Macsai, S Bertrand, D Bertrand… - International Journal of …, 2023 - mdpi.com
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the
worldwide coronavirus disease 2019 (COVID-19) pandemic. Although the pathophysiology …

Nicotinic receptors as SARS-CoV-2 spike co-receptors?

V Dormoy, JM Perotin, P Gosset, U Maskos… - Medical …, 2022 - Elsevier
Nicotinic acetylcholine receptors (nAChRs) play an important role in homeostasis and
respiratory diseases. Controversies regarding the association between COVID-19 …

In silico studies on the comparative characterization of the interactions of SARS‐CoV‐2 spike glycoprotein with ACE‐2 receptor homologs and human TLRs

A Choudhury, S Mukherjee - Journal of medical virology, 2020 - Wiley Online Library
Abstract Coronavirus disease‐2019 (COVID‐19) outbreak due to novel coronavirus or
severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection has come out as …

[HTML][HTML] Cholinergic dysfunction in COVID-19: frantic search and hoping for the best

EH Nadwa, HM Al-Kuraishy, AI Al-Gareeb… - Naunyn-Schmiedeberg's …, 2023 - Springer
A novel coronavirus known as severe acute respiratory syndrome coronavirus type 2 (SARS-
CoV-2) is a potential cause of acute respiratory infection called coronavirus disease 2019 …

[HTML][HTML] Protein structure analysis of the interactions between SARS-CoV-2 spike protein and the human ACE2 receptor: from conformational changes to novel …

I Mercurio, V Tragni, F Busto, A De Grassi… - Cellular and Molecular …, 2021 - Springer
The recent severe acute respiratory syndrome, known as Coronavirus Disease 2019
(COVID-19) has spread so much rapidly and severely to induce World Health Organization …

Molecular simulation of SARS-CoV-2 spike protein binding to pangolin ACE2 or human ACE2 natural variants reveals altered susceptibility to infection

J Wang, X Xu, X Zhou, P Chen… - Journal of General …, 2020 - microbiologyresearch.org
We constructed complex models of SARS-CoV-2 spike protein binding to pangolin or human
ACE2, the receptor for virus transmission, and estimated the binding free energy changes …