Classification of symptomatic and asymptomatic patients with and without cognitive decline using non-invasive carotid plaque strain indices as biomarkers

X Wang, DC Jackson, CC Mitchell, T Varghese… - Ultrasound in medicine …, 2016 - Elsevier
Vascular cognitive decline may be caused by micro-emboli generated by carotid plaque
instability. We previously found that maximum strain indices in carotid plaque were …

Correlation of cognitive function with ultrasound strain indices in carotid plaque

X Wang, DC Jackson, T Varghese, CC Mitchell… - Ultrasound in medicine …, 2014 - Elsevier
Instability in carotid vulnerable plaque can generate cerebral micro-emboli, which may be
related to both stroke and eventual cognitive abnormality. Strain imaging to detect plaque …

Impaired cognitive function in patients with atherosclerotic carotid stenosis and correlation with ultrasound strain measurements

BG Rocque, D Jackson, T Varghese, B Hermann… - Journal of the …, 2012 - Elsevier
INTRODUCTION: It has been postulated that up to 11 million “silent” strokes occur annually.
While these patients are without classic neurologic deficits, they may exhibit cognitive …

Estimation of ultrasound strain indices in carotid plaque and correlation to cognitive dysfunction

X Wang, DC Jackson, CC Mitchell… - 2014 36th Annual …, 2014 - ieeexplore.ieee.org
Carotid plaque prone to release emboli may be predicted by increased strain variations
within plaque due to arterial pulsation over a cardiac cycle. Non-invasive ultrasound strain …

A cross-sectional investigation of cognition and ultrasound-based vascular strain indices

NH Meshram, D Jackson, T Varghese… - Archives of Clinical …, 2020 - academic.oup.com
Objective We examine the relationship between variability in the plaque strain distribution
estimated using ultrasound with multiple cognitive domains including executive, language …

Quantification of carotid artery plaque stability with multiple region of interest based ultrasound strain indices and relationship with cognition

NH Meshram, T Varghese, CC Mitchell… - Physics in Medicine …, 2017 - iopscience.iop.org
Vulnerability and instability in carotid artery plaque has been assessed based on strain
variations using noninvasive ultrasound imaging. We previously demonstrated that carotid …

Carotid atherosclerotic plaque instability and cognition determined by ultrasound-measured plaque strain in asymptomatic patients with significant stenosis

RJ Dempsey, T Varghese, DC Jackson, X Wang… - Journal of …, 2017 - thejns.org
OBJECTIVE This article describes the use of ultrasound measurements of physical strain
within carotid atherosclerotic plaques as a measure of instability and the potential for …

[HTML][HTML] The relationship between carotid artery plaque stability and white matter ischemic injury

SE Berman, X Wang, CC Mitchell, B Kundu… - NeuroImage: Clinical, 2015 - Elsevier
Higher local carotid artery strain has previously been shown to be a characteristic of
unstable carotid plaques. These plaques may be characterized by microvascular changes …

Improved correlation of strain indices with cognitive dysfunction with inclusion of adventitial layer with carotid plaque

X Wang, CC Mitchell, T Varghese… - Ultrasonic …, 2016 - journals.sagepub.com
Plaque instability may lead to chronic embolization, which in turn may contribute to
progressive cognitive decline. Accumulated strain tensor indices over a cardiac cycle within …

[HTML][HTML] Noninvasive characterization of carotid plaque strain

AA Khan, S Sikdar, T Hatsukami, J Cebral… - Journal of vascular …, 2017 - Elsevier
Objective Current risk stratification of internal carotid artery plaques based on diameter-
reducing percentage stenosis may be unreliable because ischemic stroke results from …