SARS-CoV-2 rapidly adapts in aged BALB/c mice and induces typical pneumonia

Y Zhang, K Huang, T Wang, F Deng, W Gong… - Journal of …, 2021 - Am Soc Microbiol
Age is a risk factor for coronavirus disease 2019 (COVID-19)-associated morbidity and
mortality in humans; hence, in this study, we compared the course of severe acute …

Host and viral determinants for efficient SARS-CoV-2 infection of the human lung

H Chu, B Hu, X Huang, Y Chai, D Zhou, Y Wang… - Nature …, 2021 - nature.com
Understanding the factors that contribute to efficient SARS-CoV-2 infection of human cells
may provide insights on SARS-CoV-2 transmissibility and pathogenesis, and reveal targets …

COVID-19 and the vasculature: current aspects and long-term consequences

B Martinez-Salazar, M Holwerda, C Stuedle… - Frontiers in cell and …, 2022 - frontiersin.org
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was first identified in
December 2019 as a novel respiratory pathogen and is the causative agent of Corona Virus …

Coronil, a tri-herbal formulation, attenuates spike-protein-mediated SARS-CoV-2 viral entry into human alveolar epithelial cells and pro-inflammatory cytokines …

A Balkrishna, S Haldar, H Singh, P Roy… - Journal of …, 2021 - Taylor & Francis
Purpose: Coronil is a tri-herbal formulation containing extracts from Withania somnifera,
Tinospora cordifolia, and Ocimum sanctum. Recently, it was shown that Coronil rescued …

Could SARS-CoV-2 spike protein be responsible for long-COVID syndrome?

TC Theoharides - Molecular Neurobiology, 2022 - Springer
SARS-CoV-2 infects cells via its spike protein binding to its surface receptor on target cells
and results in acute symptoms involving especially the lungs known as COVID-19. However …

Increased susceptibility of human endothelial cells to infections by SARS-CoV-2 variants

JUG Wagner, D Bojkova, M Shumliakivska… - Basic Research in …, 2021 - Springer
Abstract Coronavirus disease 2019 (COVID-19) spawned a global health crisis in late 2019
and is caused by the novel coronavirus SARS-CoV-2. SARS-CoV-2 infection can lead to …

Liquid biomarkers of macrophage dysregulation and circulating spike protein illustrate the biological heterogeneity in patients with post‐acute sequelae of COVID‐19

C Schultheiß, E Willscher, L Paschold… - Journal of Medical …, 2023 - Wiley Online Library
Post‐acute sequelae of COVID‐19 (PASC) are long‐term consequences of SARS‐CoV‐2
infection that can substantially impair the quality of life. Underlying mechanisms ranging …

Recombinant SARS-CoV-2 spike protein stimulates secretion of chymase, tryptase, and IL-1β from human mast cells, augmented by IL-33

I Tsilioni, TC Theoharides - International Journal of Molecular Sciences, 2023 - mdpi.com
SARS-CoV-2 infects cells via its spike (S) protein binding to its surface receptor angiotensin-
converting enzyme 2 (ACE2) and results in the production of multiple proinflammatory …

Vigilance on new-onset atherosclerosis following SARS-CoV-2 infection

Y Liu, HG Zhang - Frontiers in Medicine, 2021 - frontiersin.org
The pandemic of coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, has
become a global challenge to public health. While its typical clinical manifestations are …

SARS-CoV-2 causes severe epithelial inflammation and barrier dysfunction

S Deinhardt-Emmer, S Böttcher, C Häring… - Journal of …, 2021 - Am Soc Microbiol
Infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can be
asymptomatic, but they can also be accompanied by a variety of symptoms that result in mild …