Differential proinflammatory activities of Spike proteins of SARS-CoV-2 variants of concern

SD Tyrkalska, A Martínez-López, AB Arroyo… - Science …, 2022 - science.org
The coronavirus disease 2019 (COVID-19) pandemic turned the whole world upside down
in a short time. One of the main challenges faced has been to understand COVID-19 …

[HTML][HTML] Role of senescence in the chronic health consequences of COVID-19

EOW Gerdes, G Vanichkachorn, BP Verdoorn… - Translational …, 2022 - Elsevier
While the full impact of COVID-19 is not yet clear, early studies have indicated that upwards
of 10% of patients experience COVID-19 symptoms longer than 3 weeks, known as Long …

[HTML][HTML] The skin as a critical window in unveiling the pathophysiologic principles of COVID-19

C Magro, G Nuovo, JJ Mulvey, J Laurence, J Harp… - Clinics in …, 2021 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of
coronavirus disease 2019 (COVID-19), is a single-stranded RNA virus whose sequence is …

Endothelium infection and dysregulation by SARS-CoV-2: evidence and caveats in COVID-19

I Bernard, D Limonta, LK Mahal, TC Hobman - Viruses, 2020 - mdpi.com
The ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by the acute
respiratory syndrome-coronavirus-2 (SARS-CoV-2) poses a persistent threat to global public …

Damage to endothelial barriers and its contribution to long COVID

X Wu, M Xiang, H Jing, C Wang, VA Novakovic, J Shi - Angiogenesis, 2024 - Springer
The world continues to contend with COVID-19, fueled by the emergence of viral variants. At
the same time, a subset of convalescent individuals continues to experience persistent and …

COVID-19: the vasculature unleashed

LA Teuwen, V Geldhof, A Pasut… - Nature Reviews …, 2020 - nature.com
On the basis of emerging evidence from patients with COVID-19, we postulate that
endothelial cells are essential contributors to the initiation and propagation of severe COVID …

SARS-CoV-2 spike protein dictates syncytium-mediated lymphocyte elimination

Z Zhang, Y Zheng, Z Niu, B Zhang, C Wang… - Cell Death & …, 2021 - nature.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is highly
contagious and causes lymphocytopenia, but the underlying mechanisms are poorly …

Susceptibility of the elderly to SARS-CoV-2 infection: ACE-2 overexpression, shedding, and antibody-dependent enhancement (ADE)

JPS Peron, H Nakaya - Clinics, 2020 - SciELO Brasil
The world is currently facing a serious SARS-CoV-2 infection pandemic. This virus is a new
isolate of coronavirus, and the current infection crisis has surpassed the SARS and MERS …

Extracellular Vimentin as a Target Against SARS‐CoV‐2 Host Cell Invasion

Ł Suprewicz, M Swoger, S Gupta, E Piktel, FJ Byfield… - Small, 2022 - Wiley Online Library
Infection of human cells by pathogens, including SARS‐CoV‐2, typically proceeds by cell
surface binding to a crucial receptor. The primary receptor for SARS‐CoV‐2 is the …

SARS-CoV-2 infection remodels the phenotype and promotes angiogenesis of primary human lung endothelial cells

F Caccuri, A Bugatti, A Zani, A De Palma, D Di Silvestre… - Microorganisms, 2021 - mdpi.com
SARS-CoV-2-associated acute respiratory distress syndrome (ARDS) and acute lung injury
are life-threatening manifestations of severe viral infection. The pathogenic mechanisms that …