Integrin activation is an essential component of SARS-CoV-2 infection

P Simons, DA Rinaldi, V Bondu, AM Kell, S Bradfute… - Scientific Reports, 2021 - nature.com
SARS-CoV-2 infection depends on binding its spike (S) protein to angiotensin-converting
enzyme 2 (ACE2). The S protein expresses an RGD motif, suggesting that integrins may be …

The Effects of Aβ1-42 Binding to the SARS-CoV-2 Spike Protein S1 Subunit and Angiotensin-Converting Enzyme 2

JTA Hsu, CF Tien, GY Yu, S Shen, YH Lee… - International Journal of …, 2021 - mdpi.com
Increasing evidence suggests that elderly people with dementia are vulnerable to the
development of severe coronavirus disease 2019 (COVID-19). In Alzheimer's disease (AD) …

SARS-CoV-2 spike protein S1 induces fibrin (ogen) resistant to fibrinolysis: implications for microclot formation in COVID-19

LM Grobbelaar, C Venter, M Vlok, M Ngoepe… - Bioscience …, 2021 - portlandpress.com
Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2)-induced infection, the
cause of coronavirus disease 2019 (COVID-19), is characterized by unprecedented clinical …

The function of SARS-CoV-2 spike protein is impaired by disulfide-bond disruption with mutation at cysteine-488 and by thiol-reactive N-acetyl-cysteine and …

M Murae, Y Shimizu, Y Yamamoto, A Kobayashi… - Biochemical and …, 2022 - Elsevier
Viral spike proteins play important roles in the viral entry process, facilitating attachment to
cellular receptors and fusion of the viral envelope with the cell membrane. Severe acute …

SARS-CoV-2 spike protein: a key target for eliciting persistent neutralizing antibodies

Y Yang, L Du - Signal transduction and targeted therapy, 2021 - nature.com
A recent paper published in Science describes the detection of IgG antibody responses in
individuals infected by severe acute respiratory syndrome coronavirus (SARS-CoV-2). The …

[HTML][HTML] Role of SARS-COV-2 and ACE2 in the pathophysiology of peripheral vascular diseases

H Tanzadehpanah, E Lotfian, A Avan, S Saki… - Biomedicine & …, 2023 - Elsevier
The occurrence of a novel coronavirus known as severe acute respiratory syndrome-
coronavirus-2 (SARS-CoV-2), created a serious challenge worldwide. SARS-CoV-2 has …

Relationship between endothelial and angiogenesis biomarkers envisage mortality in a prospective cohort of COVID-19 patients requiring respiratory support

F Maldonado, D Morales, C Díaz-Papapietro… - Frontiers in …, 2022 - frontiersin.org
Purpose Endothelial damage and angiogenesis are fundamental elements of
neovascularisation and fibrosis observed in patients with coronavirus disease 2019 (COVID …

COVID-19 is, in the end, an endothelial disease

P Libby, T Lüscher - European heart journal, 2020 - academic.oup.com
The vascular endothelium provides the crucial interface between the blood compartment
and tissues, and displays a series of remarkable properties that normally maintain …

Age and gender differences in ACE2 and TMPRSS2 expressions in oral epithelial cells

J Peng, J Sun, J Zhao, X Deng, F Guo… - Journal of translational …, 2021 - Springer
Abstract Background SARS-CoV-2, which has brought a huge negative impact on the world
since the end of 2019, is reported to invade cells using the spike (S) protein to bind to …

SARS-CoV-2 and endothelial cell interaction in COVID-19: molecular perspectives

R Giordo, P Paliogiannis, AA Mangoni… - Vascular …, 2021 - vb.bioscientifica.com
SARS-CoV-2 is the agent responsible for the coronavirus disease (COVID-19), which has
been declared a pandemic by the World Health Organization. The clinical evolution of …