Abstract Cholesterol 25-hydroxylase (CH25H) encodes the enzyme that converts cholesterol
to 25-hydroxycholesterol (25-HC). 25-HC has been demonstrated to be involved in the …

Inflammatory bowel disease (IBD), a general term encompassing Crohn's disease (CD) and
ulcerative colitis (UC), and other conditions, is a chronic and relapsing autoimmune disease …

Intestinal fibrosis and stenosis are common complications of Crohn's disease [CD],
frequently requiring surgery. Anti-inflammatory strategies can only partially prevent fibrosis; …

Background High-fat diet (HFD) is closely associated with the increased prevalence of
inflammatory bowel disease (IBD). Excessive gut microbial metabolite deoxycholic acid …

Hyperoside (HYP), a naturally occurring flavonoid compound, exerts multiple biological
functions including myocardial protection, antiredox, and anti-inflammatory activities …

Background Previous study found that supplements with active vitamin D3 alleviated
experimental colitis. The objective of this study was to investigate the possible role of 3 …

Background & Aims Cholesterol 25-hydroxylase (Ch25h), converting cholesterol to 25-
hydroxycholesterol (25-HC), is critical in modulating cellular lipid metabolism and anti …

Objective Expansion of visceral adipose tissue (VAT) and metabolic inflammation are
consequences of obesity and associated with type 2 diabetes (T2DM). Metabolically …

Background Ulcerative colitis [UC] is a common chronic inflammatory bowel disease without
curative treatment. Methods We conducted gene set enrichment analysis to explore potential …

Non-alcoholic fatty liver disease (NAFLD) is currently the most prevalent metabolic disorder
all over the world, and lipid metabolic disorders and inflammation are closely associated …