Radiolabeled Small-Molecule Ligands for Prostate-Specific Membrane Antigen: In vivo Imaging in Experimental Models of Prostate Cancer

CA Foss, RC Mease, H Fan, Y Wang, HT Ravert… - Clinical cancer …, 2005 - AACR
Purpose: Prostate-specific membrane antigen (PSMA) is a cell surface protein that is
overexpressed in prostate cancer, including hormone-refractory and metastatic disease. Our …

99mTc-labeled small-molecule inhibitors of prostate-specific membrane antigen for molecular imaging of prostate cancer

SM Hillier, KP Maresca, G Lu, RD Merkin… - Journal of Nuclear …, 2013 - Soc Nuclear Med
Prostate-specific membrane antigen (PSMA) is highly expressed in prostate cancer, and
small-molecule radiopharmaceuticals targeting PSMA rapidly detect the location and extent …

99mTc-labeled small-molecule inhibitors of prostate-specific membrane antigen: pharmacokinetics and biodistribution studies in healthy subjects and patients with …

S Vallabhajosula, A Nikolopoulou… - Journal of Nuclear …, 2014 - Soc Nuclear Med
Prostate-specific membrane antigen (PSMA) is a well-established target for developing
radiopharmaceuticals for imaging and therapy of prostate cancer (PCa). We have recently …

[HTML][HTML] Prostate specific membrane antigen—a target for imaging and therapy with radionuclides

K Bouchelouche, PL Choyke, J Capala - Discovery medicine, 2010 - ncbi.nlm.nih.gov
Prostate cancer continues to represent a major health problem, and yet there is no effective
treatment available for advanced metastatic disease. Thus, there is an urgent need for the …

[HTML][HTML] Prostate-specific membrane antigen as a target for cancer imaging and therapy

AP Kiess, SR Banerjee, RC Mease… - The quarterly journal …, 2015 - ncbi.nlm.nih.gov
The prostate-specific membrane antigen (PSMA) is a molecular target whose use has
resulted in some of the most productive work toward imaging and treating prostate cancer …

Synthesis and evaluation of technetium-99m-and rhenium-labeled inhibitors of the prostate-specific membrane antigen (PSMA)

SR Banerjee, CA Foss, M Castanares… - Journal of medicinal …, 2008 - ACS Publications
The prostate-specific membrane antigen (PSMA) is increasingly recognized as a viable
target for imaging and therapy of cancer. We prepared seven 99mTc/Re-labeled compounds …

Imaging of nonprostate cancers using PSMA-targeted radiotracers: rationale, current state of the field, and a call to arms

RAS Fragomeni, T Amir, S Sheikhbahaei… - Journal of Nuclear …, 2018 - Soc Nuclear Med
Prostate-specific membrane antigen (PSMA) is a type II transmembrane glycoprotein that is
highly overexpressed on prostate cancer epithelial cells and for which there is a growing …

Prostate-specific membrane antigen targeted imaging and therapy of prostate cancer using a PSMA inhibitor as a homing ligand

SA Kularatne, K Wang, HKR Santhapuram… - Molecular …, 2009 - ACS Publications
Prostate cancer (PCa) is a major cause of mortality and morbidity in Western society today.
Current methods for detecting PCa are limited, leaving most early malignancies …

Preclinical evaluation of novel glutamate-urea-lysine analogues that target prostate-specific membrane antigen as molecular imaging pharmaceuticals for prostate …

SM Hillier, KP Maresca, FJ Femia, JC Marquis… - Cancer research, 2009 - AACR
Prostate-specific membrane antigen (PSMA) is expressed in normal human prostate
epithelium and is highly up-regulated in prostate cancer. We previously reported a series of …

PSMA-targeted radiopharmaceuticals for imaging and therapy

HJ Wester, M Schottelius - Seminars in nuclear medicine, 2019 - Elsevier
As described in more detail in other contributions in this issue of Seminars in Nuclear
Medicine, prostate-specific membrane antigen (PSMA) has become one of the most …