Under conditions of extreme heat stress, the process of autophagy has previously been
shown to protect human cells, but the exact body temperature at which autophagic activation …

With the increasing threat of climate change and the accompanying rise in the frequency
and severity of extreme heat events, there are growing health concerns for heat-vulnerable …

Hypothermia is a critical consequence of extreme cold exposure that increases the risk of
cold-related injury and death in humans. While the initiation of cytoprotective mechanisms …

Autophagy is essential to maintaining cellular homeostasis in all eukaryotic cells and to
tolerance of acute stressors such as starvation, heat, and recovery after exercise. Limited …

With rising global temperatures, heat-related mortality is increasing, particularly among older
adults. Although this is often attributed to declines in thermoregulatory function, little is …

Hyperthermia is a promising anticancer treatment used in combination with radiotherapy
and chemotherapy. Temperatures above 41.5° C are cytotoxic and hyperthermia treatments …

Autophagy is a vital cellular process, essential to maintaining cellular function during acute
physiological stressors including exercise and heat stress. We previously showed that …

The exposure to low doses of stress induces an adaptive survival response that involves
upregulation of cellular defense systems such as heat shock proteins (Hsp), anti-apoptosis …

Heat waves can cause dangerous elevations in body temperature that can compromise
cellular function and increase the risk of heat stroke and major cardiovascular events …

Heat-stress-induced dehydration is associated with extracellular hyperosmolality. To
counteract the associated stress, cells employ cytoprotective mechanisms, including …