Agents that remodel the tumor microenvironment (TME), prime functional tumor-specific T
cells, and block inhibitory signaling pathways are essential components of effective …

Listeria monocytogenes, a facultative intracellular bacterium, can induce a potent antitumor
immune response if engineered to express a model tumor antigen also expressed by the …

Background We previously demonstrated that in addition to generating an antigen-specific
immune response, Listeria monocytogenes (Lm)-based immunotherapy significantly …

Improved immunization and ex vivo T-cell culture strategies can generate larger numbers
and more potent tumor-specific effector cells than previously possible. Nonetheless, the …

Myeloid-derived suppressor cells (MDSC) and regulatory T cells (Treg) are major
components of the immune suppressive cells that potentially limit the effectiveness of an …

The promise of tumor immunotherapy to significantly improve survival in patients who are
refractory to long-standing therapies, such as chemotherapy and radiation, is now being …

Background One of the significant tumor immune escape mechanisms and substantial
barrier for successful immunotherapy is tumor-mediated inhibition of immune response …

For over a century, inactivated or attenuated bacteria have been employed in the clinic as
immunotherapies to treat cancer, starting with the Coley's vaccines in the 19th century and …

Abstract Purpose of Review Immunotherapy has emerged as a promising cancer treatment;
however, success in only select clinical indications underscores the need for novel …

Cancer receives enduring international attention due to its extremely high morbidity and
mortality. Immunotherapy, which is generally expected to overcome the limits of traditional …