Theoretical considerations on quantitative prediction of drug-drug interactions
A Hisaka, Y Ohno, T Yamamoto, H Suzuki - Drug metabolism and …, 2010 - Elsevier
The prediction of drug-drug interactions (DDIs) associated with change in clearance for
metabolism is reviewed, particularly focusing on pharmacokinetic theories for prediction …
metabolism is reviewed, particularly focusing on pharmacokinetic theories for prediction …
Use of clearance concepts and modeling techniques in the prediction of metabolic drug–drug interactions
K Ito, Y Sugiyama - Trends in pharmacological sciences, 2010 - cell.com
Quantitative prediction of the in vivo drug–drug interactions (DDIs) caused by metabolic
inhibition, one of the most common DDI mechanisms in clinical practice, has long been …
inhibition, one of the most common DDI mechanisms in clinical practice, has long been …
Prediction of pharmacokinetics and drug-drug interactions from in vitro metabolism data.
M Shou - Current opinion in drug discovery & development, 2005 - europepmc.org
There is great interest within the pharmaceutical industry in predicting the in vivo
pharmacokinetics (PKs) and metabolism-based drug-drug interactions (DDIs) of compounds …
pharmacokinetics (PKs) and metabolism-based drug-drug interactions (DDIs) of compounds …
Predicting drug-drug interactions from in vitro drug metabolism data: challenges and recent advances.
RS Obach - Current opinion in drug discovery & development, 2009 - europepmc.org
Drug-drug interactions (DDI) caused by the inhibition, inactivation or induction of cytochrome
P450 enzymes have been an area of intense research. Models to predict DDI from in vitro …
P450 enzymes have been an area of intense research. Models to predict DDI from in vitro …
An update on the potential role of intestinal first-pass metabolism for the prediction of drug–drug interactions: The role of PBPK modeling
S Alqahtani, I Bukhari, A Albassam… - Expert Opinion on Drug …, 2018 - Taylor & Francis
Introduction: The intestinal absorption process is a combination of several events that are
governed by various factors. Several transport mechanisms are involved in drug absorption …
governed by various factors. Several transport mechanisms are involved in drug absorption …
Impact of ignoring extraction ratio when predicting drug-drug interactions, fraction metabolized, and intestinal first-pass contribution
BJ Kirby, JD Unadkat - Drug metabolism and disposition, 2010 - ASPET
Many mathematical models for in vitro to in vivo prediction of drug-drug interactions (DDIs) of
orally administered victim drugs have been developed. However, to date, none of these …
orally administered victim drugs have been developed. However, to date, none of these …
Dealing with the complex drug–drug interactions: towards mechanistic models
MV Varma, KS Pang, N Isoherranen… - … & drug disposition, 2015 - Wiley Online Library
Unmanageable severe adverse events caused by drug‐drug interactions (DDIs), leading to
market withdrawals or restrictions in the clinical usage, are increasingly avoided with the …
market withdrawals or restrictions in the clinical usage, are increasingly avoided with the …
Evaluation of the use of static and dynamic models to predict drug-drug interaction and its associated variability: impact on drug discovery and early development
SA Peters, PE Schroeder, N Giri, H Dolgos - Drug Metabolism and …, 2012 - ASPET
Simcyp, a population-based simulator, is widely used for evaluating drug-drug interaction
(DDI) risks in healthy and disease populations. We compare the prediction performance of …
(DDI) risks in healthy and disease populations. We compare the prediction performance of …
Predicting drug-drug interactions involving the inhibition of intestinal CYP3A4 and P-glycoprotein
T Tachibana, M Kato, J Takano… - Current drug …, 2010 - ingentaconnect.com
Recently, interest has grown in drug-drug interactions (DDIs) involving the inhibition of
intestinal CYP3A4, P-glycoprotein (P-gp), and other drug efflux transporters. The criteria for …
intestinal CYP3A4, P-glycoprotein (P-gp), and other drug efflux transporters. The criteria for …
Prediction of In Vivo Drug-Drug Interactions from In Vitro Data: Factors Affecting Prototypic Drug-Drug Interactions Involving CYP2C9, CYP2D6 and CYP3A4
HS Brown, A Galetin, D Hallifax, JB Houston - Clinical pharmacokinetics, 2006 - Springer
Background Quantitative predictions of in vivo drug-drug interactions (DDIs) resulting from
metabolic inhibition are commonly made based upon the inhibitor concentration at the …
metabolic inhibition are commonly made based upon the inhibitor concentration at the …