Mitochondria are cellular organelles that orchestrate a vast range of biological processes,
from energy production and metabolism to cell death and inflammation. Despite this …

Mitochondrial DNA (mtDNA) has many similarities with bacterial DNA because of their
shared common ancestry. Increasing evidence demonstrates mtDNA to be a potent danger …

Mitochondria are master regulators of metabolism and have emerged as key signalling
organelles of the innate immune system. Each mitochondrion harbours potent agonists of …

Mitochondrial DNA (mtDNA)—which is well known for its role in oxidative phosphorylation
and maternally inherited mitochondrial diseases—is increasingly recognized as an agonist …

Inflammation benefits the host by promoting the elimination of invading pathogens and
clearance of cellular debris after tissue injury. Inflammation also stimulates tissue repair and …

Besides their role in cell metabolism, mitochondria display many other functions.
Mitochondrial DNA (mtDNA), the own genome of the organelle, plays an important role in …

Mitochondrion is known as the energy factory of the cell, which is also a unique mammalian
organelle and considered to be evolved from aerobic prokaryotes more than a billion years …

According to the endosymbiotic theory, most of the DNA of the original bacterial
endosymbiont has been lost or transferred to the nucleus, leaving a much smaller (∼ 16 kb …

Mitochondria have emerged as key drivers of mammalian innate immune responses,
functioning as signaling hubs to trigger inflammation and orchestrating metabolic switches …

The mammalian genome comprises nuclear DNA (nDNA) derived from both parents and
mitochondrial DNA (mtDNA) that is maternally inherited and encodes essential proteins …