Base-mediated diastereoselective [4+ 3] annulation of in situ generated ortho-quinone methides with C, N-cyclic azomethine imines

J Xu, S Yuan, J Peng, M Miao, Z Chen… - Organic & Biomolecular …, 2017 - pubs.rsc.org
An efficient [4+ 3] annulation of 2-(1-tosylalkyl) phenols with C, N-cyclic azomethine imines
via in situ generation of ortho-quinone methides (o-QMs) under mild basic reaction …

One-pot regioselective synthesis of 2, 4-disubstituted quinolines via copper (II)-catalyzed cascade annulation

W Wu, Y Guo, X Xu, Z Zhou, X Zhang, B Wu… - Organic Chemistry …, 2018 - pubs.rsc.org
A copper (II)-catalyzed cascade annulation of simple anilines with two molecules of alkyne
esters for the one-pot synthesis of 2, 4-disubstituted quinolines, with exclusive …

Rapid Assembly of Functionalized 2H-Chromenes and 1,2-Dihydroquinolines via Microwave-Assisted Secondary Amine-Catalyzed Cascade Annulation of 2-O/N …

D Rajput, G Jan, M Karuppasamy… - The Journal of …, 2023 - ACS Publications
An efficient, secondary amine-catalyzed cascade annulation of 2-O/N-
propargylarylaldehydes with 2, 6-dialkylphenols was established to access biologically …

Diastereoselective Synthesis of Tetrahydroquinolines Bearing Oxindole Scaffolds via Annulation of in Situ Generated p‐Quinone Methides

J Wang, L Zhao, L Zhao, X Pan, C Lv… - Advanced Synthesis …, 2020 - Wiley Online Library
Abstract A diastereoselective [4+ 2] annulation reaction between in situ generated p‐
quinone methides and isatin‐derived enoates has been developed. In the presence of …

Synthesis of polysubstituted quinolines through promoter-regulated selective annulation and C–C bond cleavage from 2-styrylanilines and β-keto esters

H Xu, F Yu, R Huang, M Weng, H Chen… - Organic Chemistry …, 2020 - pubs.rsc.org
A powerful construction of 2-alkylquinolines and quinoline-2-carboxylates has been
successfully accomplished employing I2 and Mn (OAc) 3, respectively, to promote the …

A highly diastereoselective [5+ 1] annulation to 2, 2, 3-trisubstituted tetrahydroquinoxalines via intramolecular Mannich-type trapping of ammonium ylides

XY Guan, M Tang, ZQ Liu, WH Hu - Chemical Communications, 2019 - pubs.rsc.org
A novel tandem intermolecular ammonium ylide formation/intramolecular Mannich-type [5+
1] cyclization reaction of aryl diazoacetates and ortho-aminophenyl imine derivatives was …

Solvent-controlled divergent annulation of ynones and (iso) quinoline N-oxides: of 3-((iso) quinolin-1-yl)-4 H-chromen-4-ones and 13 H-isoquinolino [2, 1-a] quinolin …

WW Yang, LL Chen, P Chen, YF Ye… - Chemical …, 2020 - pubs.rsc.org
An effective annulation of ynones and (iso) quinoline N-oxides was developed to deliver
various functionalized 3-((iso) quinolin-1-yl)-4H-chromen-4-ones and 13H-isoquinolino [2, 1 …

Acid-catalysed intramolecular Friedel–Crafts annulation of hetero-atom-functionalized para-quinone methides: access to O-, S-and N-based heterocycles

S Sharma, G Singh, M Kumar, RV Anand - Organic & Biomolecular …, 2023 - pubs.rsc.org
We describe here an acid-mediated one-pot approach to access substituted xanthene and
thioxanthane derivatives from ortho-heteroaryl phenyl-substituted para-quinone methides …

Formal [4 + 2] Annulation of Oxindole-Embedded ortho-Quinone Methides with 1,3-Dicarbonyls: Synthesis of Spiro[Chromen-4,3′-Oxindole] Scaffolds

YB Shen, SS Li, X Liu, L Yu, YM Sun… - The Journal of Organic …, 2019 - ACS Publications
The oxindole-embedded ortho-quinone methides were employed as reactive intermediates
in formal [4+ 2] annulation with 1, 3-dicarbonyls, providing an efficient access to spiro …

Concise synthesis of pyrrolo [3, 4-c] quinolines via a P (NMe 2) 3-catalyzed [4+ 2] annulation followed by a Zn/AcOH-mediated reduction–hydroamination …

Z Chen, D Xiong, N Wang, Y Zhang, H Yao… - Organic Chemistry …, 2024 - pubs.rsc.org
AP (NMe2) 3-catalyzed [4+ 2] annulation of 2-amino-β-nitrostyrenes and β′-acetoxy
allenoates followed by a Zn/AcOH-mediated reduction–hydroamination–isomerization has …