Epigenetic biomarkers in cell-free DNA and applications in liquid biopsy

W Gai, K Sun - Genes, 2019 - mdpi.com
Cell-free circulating DNA (cfDNA) in plasma has gained global interest as a diagnostic
material for noninvasive prenatal testing and cancer diagnosis, or the so-called “liquid …

Liquid biopsies: DNA methylation analyses in circulating cell-free DNA

H Zeng, B He, C Yi, J Peng - Journal of genetics and genomics, 2018 - Elsevier
Abstract Analysis of patient's materials like cells or nucleic acids obtained in a minimally
invasive or noninvasive manner through the sampling of blood or other body fluids serves as …

Toward the early detection of cancer by decoding the epigenetic and environmental fingerprints of cell-free DNA

Y Van Der Pol, F Mouliere - Cancer cell, 2019 - cell.com
Widespread adaptation of liquid biopsy for the early detection of cancer has yet to reach
clinical utility. Circulating tumor DNA is commonly detected though the presence of genetic …

Current and future perspectives of cell-free DNA in liquid biopsy

S Liu, J Wang - Current Issues in Molecular Biology, 2022 - mdpi.com
A liquid biopsy is a minimally invasive or non-invasive method to analyze a range of tumor
material in blood or other body fluids, including circulating tumor cells (CTCs), cell-free DNA …

Circulating cell-free DNA for cancer early detection

Q Gao, Q Zeng, Z Wang, C Li, Y Xu, P Cui, X Zhu, H Lu… - The Innovation, 2022 - cell.com
Effective screening modalities are currently available for only a small subset of cancers, and
they generally have suboptimal performance with complicated procedures. Therefore, there …

Bioinformatics analysis for circulating cell-free DNA in cancer

CC Huang, M Du, L Wang - Cancers, 2019 - mdpi.com
Molecular analysis of cell-free DNA (cfDNA) that circulates in plasma and other body fluids
represents a “liquid biopsy” approach for non-invasive cancer screening or monitoring. The …

Impact of preanalytical and analytical methods on cell-free DNA diagnostics

J Krasic, I Abramovic, A Vrtaric… - Frontiers in cell and …, 2021 - frontiersin.org
While tissue biopsy has for the longest time been the gold-standard in biomedicine,
precision/personalized medicine is making the shift toward liquid biopsies. Cell-free DNA …

Cell-free DNA fragmentomics in liquid biopsy

SC Ding, YMD Lo - Diagnostics, 2022 - mdpi.com
Cell-free DNA (cfDNA) in bodily fluids has rapidly transformed the development of
noninvasive prenatal testing, cancer liquid biopsy, and transplantation monitoring. Plasma …

Simultaneous analysis of mutations and methylations in circulating cell-free DNA for hepatocellular carcinoma detection

P Wang, Q Song, J Ren, W Zhang, Y Wang… - Science translational …, 2022 - science.org
Cell-free DNA (cfDNA)–based liquid biopsy is a promising approach for the early detection
of cancer. A major hurdle is the limited yield of cfDNA from one blood draw, limiting the use …

[HTML][HTML] Liver-derived cell-free nucleic acids in plasma: Biology and applications in liquid biopsies

P Jiang, KCA Chan, YMD Lo - Journal of hepatology, 2019 - Elsevier
There is much global research interest surrounding the use of cell-free DNA (cfDNA) for
liquid biopsies. cfDNA-based non-invasive prenatal testing for foetal chromosomal …