Ischemia-reperfusion injuries (IRI) occur in different clinical conditions such as stroke,
trauma, organ transplantation, and so on. Ischemia damages mainly arise from oxygen …

Silymarin 'milk thistle'(Silybum marianum) plant, has been used for years for treatment of
different diseases such as liver and gallbladder disorders, protecting liver against snake bite …

Cardiac disorders remain one of the most important causes of death in the world. Oxidative
stress has been suggested as one of the molecular mechanisms involved in drug-induced …

Sepsis is a leading cause of death among intensive care patients. During sepsis,
exaggerated reaction to infection leads to massive production of reactive oxygen species …

Silymarin and silibinin are bioactive components isolated from Silybum marianum. They
have been reported to exhibit anti-oxidative and anti-inflammatory effects. Many studies …

BACKGROUND There is comprehensive experimental and clinical evidence that either
exogenous supplementation of natural antioxidants or augmentation of endogenous …

Background Renal ischemia/reperfusion (I/R) injury is a major cause of acute renal failure.
Silymarin is extracted from Silybum marianum and Cynara cardunculus seeds and fruits …

BACKGROUND: Sepsis is associated with enhanced generation of reactive oxygen species,
which leads to multiple organ dysfunctions. Based on the potent antioxidant effects of …

Widespread use of herbal drugs because of their protective effects on different organs
toxicity has been shown in many studies. These protective effects have been illustrated in …

Silibinin/silymarin has been used in herbal medicine for thousands of years and it is well-
known for its hepato-protective properties. The present comprehensive literature review …