We report that BMI1 promotes tamoxifen resistance in estrogen receptor (ER)-positive breast
cancer (BC). BMI1 overexpression conferred MCF7 and TD47 cells resistance to tamoxifen; …

Bmi-1, a polycomb gene family member, plays an important role in cell cycle regulation, cell
immortalization, and cell senescence. Recently, numerous studies have demonstrated that …

There is increasing evidence that a variety of cancers arise from transformation of normal
stem cells to cancer stem cells (CSCs). CSCs are thought to sustain cancer progression …

Abstract Background The Bmi1 polycomb ring finger oncogene, a transcriptional repressor
belonging to the Polycomb group of proteins plays an important role in the regulation of stem …

The BMI1 oncogene promotes prostate cancer (PC) progression. High B‐cell‐specific
Moloney murine leukemia virus integration site 1 (BMI1) expression predicts poor prognosis …

The bmi-1 and myc oncogenes collaborate strongly in murine lymphomagenesis, but the
basis for this collaboration was not understood. We recently identified the ink4a–ARF tumor …

Doxorubicin and other anthracycline compounds exert their anti-cancer effects by causing
DNA damage and initiating cell cycle arrest in cancer cells, followed by apoptosis. DNA …

Chronic pancreatitis and pancreatic ductal adenocarcinoma (PDAC) are associated with
major changes in cell differentiation. These changes may be at the basis of the increased …

BMI-1, also known as a stem cell factor, is frequently upregulated in several malignancies.
Elevated expression of BMI-1 correlates with poor prognosis and is therefore considered a …

B-lymphoma Moloney murine leukaemia virus insertion region-1 (BMI1) is a member of the
polycomb group of transcription repressors, which functions in stem cell maintenance and …