Publisher Summary The role for interleukin-1 (IL-1) in mediating the consequences of
infection, particularly bacterial infection, is presented in the chapter. Administration of IL-1 to …

Data that implicate cytokines in infectious diseases are derived from studies in which
bacterial products such as lipopolysaccharide (LPS) endotoxins from Gram-negative …

Abstract Interleukin-1 (IL-1) is one of several proinflammatory cytokines produced during
infection, sepsis, and the systemic inflammatory response syndrome (SIRS) that serves to …

The polypeptide cytokine interleukin-1 (IL-1) affects nearly every tissue and organ system. IL-
1 is the prototype of the pro-inflammatory cytokines in that it induces the expression of a …

In addition to activating T and B lymphocytes, interleukin 1 (IL-1) induces several
hematologic and metabolic changes typical of host responses to infection and injury. We …

During inflammation, injury, immunological challenge or infection, interleukin-1 appears to
mediate, in part, the pathogenesis, of disease. Most studies on interleukin-1 are derived from …

Although the experimental administration of IL-1 induces several aspects of the inflammatory
response, such as fever, tachycardia, and acute phase proteinemia, the contribution of IL-1 …

Interleukin-I (IL-1) is the prototypic pro-inflammatory cytokine. There are two forms of IL-1, IL-
1α and IL-Iβ and in most studies, their biological activities are indistinguishable. IL-1 affects …

Interleukin 1 (IL-1) is an endogenously produced cytokine that mediates a variety of
physiological effects that may be beneficial or deleterious to the host. C57Bl/6 mice treated …

Interleukin-1 (IL-1) is primarily an inflammatory cytokine. Biologically, IL-1 is more closely
related to tumor necrosis factor (TNF) than any other cytokine or interleukin, although the …