Biodegradable drug-delivery peptide nanocapsules

EM Wessel, JM Tomich, RB Todd - ACS omega, 2019 - ACS Publications
Branched amphiphilic peptide capsules (BAPCs) are an efficient transport system that can
deliver nucleic acids, small proteins, and solutes. The ability of BAPCs to break down is …

Evaluation of transfection efficacy, biodistribution, and toxicity of branched amphiphilic peptide capsules (BAPCs) associated with mRNA

N Kunte, M Westerfield, E McGraw, J Choi… - Biomaterials …, 2022 - pubs.rsc.org
Nanoparticles (NPs) have been shown to be a suitable mRNA delivery platform by
conferring protection against ribonucleases and facilitating cellular uptake. Several NPs …

Delivery of lethal dsRNAs in insect diets by branched amphiphilic peptide capsules

SM Barros, R Chandrasekar… - The FASEB …, 2019 - Wiley Online Library
Branched Amphiphilic Peptides Capsules (BAPCs™) are a novel class of nano‐carriers
constituted from the spontaneous co‐assembly of two unique, engineered peptide …

Branched amphiphilic cationic oligopeptides form peptiplexes with DNA: a study of their biophysical properties and transfection efficiency

LA Avila, LRMM Aps, P Sukthankar… - Molecular …, 2015 - ACS Publications
Over the past decade, peptides have emerged as a new family of potential carriers in gene
therapy. Peptides are easy to synthesize and quite stable. Additionally, sequences shared …

Branched amphipathic peptide capsules: different ratios of the two constituent peptides direct distinct bilayer structures, sizes, and DNA transfection efficiency

SM Barros, LA Avila, SK Whitaker, KE Wilkinson… - Langmuir, 2017 - ACS Publications
Branched amphipathic peptide capsules (BAPCs) are biologically derived, bilayer delimited,
nanovesicles capable of being coated by or encapsulating a wide variety of solutes. The …

Amyloid-like self-assembly of a hydrophobic cell-penetrating peptide and its use as a carrier for nucleic acids

LR de Mello, L Porosk, TC Lourenço… - ACS Applied Bio …, 2021 - ACS Publications
Cell-penetrating peptides (CPPs) are a topical subject potentially exploitable for creating
nanotherapeutics for the delivery of bioactive loads. These compounds are often classified …

[HTML][HTML] Nanocarrier system: An emerging strategy for bioactive peptide delivery

X Zhang, X Li, Y Zhao, Q Zheng, Q Wu, Y Yu - Frontiers in Nutrition, 2022 - frontiersin.org
Compared with small-molecule synthetic drugs, bioactive peptides have desirable
advantages in efficiency, selectivity, safety, tolerance, and side effects, which are accepted …

[HTML][HTML] Toward Artificial Peptide Nanocapsules

Y Wang, B Chen - Nano-Micro Letters, 2024 - Springer
Highlights The formation of peptide nanocapsules is facilitated by a gradient interface,
where the differential solvent concentration drives the peptides to preferentially localize and …

Macrocyclic peptides self-assemble into robust vesicles with molecular recognition capabilities

W Jeong, Y Lim - Bioconjugate Chemistry, 2014 - ACS Publications
In this study, we developed macrocyclic peptide building blocks that formed self-assembled
peptide vesicles with molecular recognition capabilities. Macrocyclic peptides were …

Engineered protein nanocages for concurrent RNA and protein packaging in vivo

S Kwon, TW Giessen - ACS synthetic biology, 2022 - ACS Publications
Protein nanocages have emerged as an important engineering platform for biotechnological
and biomedical applications. Among naturally occurring protein cages, encapsulin …