Neurodegenerative diseases are rarely caused by a mutation in a single gene but rather
influenced by a combination of genetic, epigenetic and environmental factors. Emerging …

Network biology has become a powerful tool to dissect the molecular mechanisms triggering
neurodegeneration. Recent developments in network biology have led to the discovery of …

The recent methodological advances in multi-omics approaches, including genomic,
transcriptomic, metabolomic, lipidomic, and proteomic, have revolutionized the research …

The cellular mechanisms underlying the stereotypical progression of pathology in
neurodegenerative diseases are incompletely understood, but increasing evidence …

Classical biological methods involving analyses of one or several genes have been the
mainstay for studying the pathogenesis of neurodegenerative disorders. However, it has …

Although the genetic causes for several rare, familial forms of Alzheimer's disease (AD) have
been identified, the etiology of the sporadic form of AD remains unclear. Here, we report a …

Neurodegenerative diseases are the most common cause of dementia. Although their
underlying molecular pathologies have been identified, there is substantial heterogeneity in …

Integration of multi-omics data with molecular interaction networks enables elucidation of the
pathophysiology of Alzheimer's disease (AD). Using the latest genome-wide association …

By 2050 it is estimated that the number of worldwide Alzheimer's disease (AD) patients will
quadruple from the current number of 36 million people. To date, no single test, prior to …

Alzheimer's disease (AD) is a polygenic multifactorial neurodegenerative disease that, after
decades of research and development, is still without a cure. There are some symptomatic …