ABSTRACT tRNAs play a critical role in mRNA decoding, and posttranscriptional
modifications within tRNAs drive decoding efficiency and accuracy. The types and positions …

Nucleoside modification has been studied in unfractionated tRNA from 11 thermophilic
archaea (archaebacteria), including phylogenetically diverse representatives of thermophilic …

From 50 genomes of the three domains of life (7 eukarya, 13 archaea, and 30 bacteria), we
extracted, analyzed, and compared over 4,000 sequences corresponding to cytoplasmic …

tRNA modifications are important for decoding, translation accuracy, and structural integrity
of tRNAs. Archaeal tRNAs contain at least 47 different tRNA modifications, some of them …

The modification of adenosine to inosine at position 34 of tRNA anticodons has a profound
impact upon codon-anticodon recognition. In bacteria, I34 is thought to exist only in …

To improve and complete our knowledge of archaeal tRNA modification patterns, we have
identified and compared the modification pattern (type and location) in tRNAs of three very …

We report the first study of tRNA modification in psychrotolerant archaea, specifically in the
archaeon Methanococcoides burtonii grown at 4 and 23° C. For comparison, unfractionated …

The biogenesis of tRNA involves multiple reactions including post-transcriptional
modifications and pre-tRNA splicing. Among the three domains of life, only Archaea have …

Following a search of the Pyrococcus genomes for homologs of eukaryotic methylation
guide small nucleolar RNAs, we have experimentally identified in Pyrococcus abyssi four …

Transfer RNA (tRNA) gene content is a differentiating feature of genomes that contributes to
the efficiency of the translational apparatus, but the principles shaping tRNA gene copy …