Genome-wide association analysis in humans links nucleotide metabolism to leukocyte telomere length

C Li, S Stoma, LA Lotta, S Warner, E Albrecht… - The American Journal of …, 2020 - cell.com
Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging. In this study, we
perform a genome-wide meta-analysis of LTL by pooling densely genotyped and imputed …

Identification of seven loci affecting mean telomere length and their association with disease

V Codd, CP Nelson, E Albrecht, M Mangino, J Deelen… - Nature …, 2013 - nature.com
Interindividual variation in mean leukocyte telomere length (LTL) is associated with cancer
and several age-associated diseases. We report here a genome-wide meta-analysis of …

Loci for human leukocyte telomere length in the Singaporean Chinese population and trans-ethnic genetic studies

R Dorajoo, X Chang, RL Gurung, Z Li, L Wang… - Nature …, 2019 - nature.com
Genetic factors underlying leukocyte telomere length (LTL) may provide insights into
telomere homeostasis, with direct links to disease susceptibility. Genetic evaluation of …

Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans

M Mangino, SJ Hwang, TD Spector… - Human molecular …, 2012 - academic.oup.com
Leukocyte telomere length (LTL) is associated with a number of common age-related
diseases and is a heritable trait. Previous genome-wide association studies (GWASs) …

Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed

MA Taub, MP Conomos, R Keener, KR Iyer… - Cell Genomics, 2022 - cell.com
Genetic studies on telomere length are important for understanding age-related diseases.
Prior GWASs for leukocyte TL have been limited to European and Asian populations. Here …

Genome wide association and linkage analyses identified three loci—4q25, 17q23. 2, and 10q11. 21—associated with variation in leukocyte telomere length: the …

JH Lee, R Cheng, LS Honig, M Feitosa… - Frontiers in …, 2014 - frontiersin.org
Leukocyte telomere length is believed to measure cellular aging in humans, and short
leukocyte telomere length is associated with increased risks of late onset diseases …

Association between leucocyte telomere length and cardiovascular disease in a large general population in the United States

C Xu, Z Wang, X Su, M Da, Z Yang, W Duan, X Mo - Scientific reports, 2020 - nature.com
Leucocyte telomere length (LTL) has been reported to be linked to ageing, cancer and
cardiovascular disease (CVD). This study aimed to explore the association between LTL …

Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants

CL Kuo, LC Pilling, GA Kuchel, L Ferrucci… - Aging cell, 2019 - Wiley Online Library
Inherited genetic variation influencing leukocyte telomere length provides a natural
experiment for testing associations with health outcomes, more robust to confounding and …

Polygenic basis and biomedical consequences of telomere length variation

V Codd, Q Wang, E Allara, C Musicha, S Kaptoge… - Nature …, 2021 - nature.com
Telomeres, the end fragments of chromosomes, play key roles in cellular proliferation and
senescence. Here we characterize the genetic architecture of naturally occurring variation in …

A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk

KA Pooley, SE Bojesen, M Weischer… - Human molecular …, 2013 - academic.oup.com
Mean telomere length (TL) in blood cells is heritable and has been reported to be
associated with risks of several diseases, including cancer. We conducted a meta-analysis …