TRIM44 links the UPS to SQSTM1/p62-dependent aggrephagy and removing misfolded proteins
L Lyu, Z Chen, N McCarty - Autophagy, 2022 - Taylor & Francis
Until recently, the ubiquitin-proteasome system (UPS) and macroautophagy/autophagy were
considered to be two independent systems that target proteins for degradation by …
considered to be two independent systems that target proteins for degradation by …
TRIM22 facilitates autophagosome-lysosome fusion by mediating the association of GABARAPs and PLEKHM1
H Heo, H Park, MS Lee, J Kim, J Kim, SY Jung… - Autophagy, 2024 - Taylor & Francis
Tripartite motif (TRIM) proteins are a large family of E3 ubiquitin ligases implicated in
antiviral defense systems, tumorigenesis, and protein quality control. TRIM proteins …
antiviral defense systems, tumorigenesis, and protein quality control. TRIM proteins …
TRIM37 deficiency induces autophagy through deregulating the MTORC1-TFEB axis
ABSTRACT TRIM37 gene mutations cause mulibrey (muscle-liver-brain-eye) nanism, a
severe growth disorder with prenatal onset. Although TRIM37 depletion normally induces …
severe growth disorder with prenatal onset. Although TRIM37 depletion normally induces …
TRIM16 governs the biogenesis and disposal of stress-induced protein aggregates to evade cytotoxicity: implication for neurodegeneration and cancer
The formation of protein aggregates is linked to several diseases collectively called
proteinopathies. The mechanisms and the molecular players that control the turnover of …
proteinopathies. The mechanisms and the molecular players that control the turnover of …
TRIM59 regulates autophagy through modulating both the transcription and the ubiquitination of BECN1
T Han, M Guo, M Gan, B Yu, X Tian, JB Wang - Autophagy, 2018 - Taylor & Francis
Macroautophagy/autophagy is a multistep cellular process that sequesters cytoplasmic
components for lysosomal degradation. BECN1/Beclin1 is a central protein that assembles …
components for lysosomal degradation. BECN1/Beclin1 is a central protein that assembles …
[HTML][HTML] TRIM11 activates the proteasome and promotes overall protein degradation by regulating USP14
The proteasome is a complex protease critical for protein quality control and cell regulation,
and its dysfunction is associated with cancer and other diseases. However, the mechanisms …
and its dysfunction is associated with cancer and other diseases. However, the mechanisms …
[HTML][HTML] UXT chaperone prevents proteotoxicity by acting as an autophagy adaptor for p62-dependent aggrephagy
MJ Yoon, B Choi, EJ Kim, J Ohk, C Yang… - Nature …, 2021 - nature.com
Abstract p62/SQSTM1 is known to act as a key mediator in the selective autophagy of
protein aggregates, or aggrephagy, by steering ubiquitinated protein aggregates towards …
protein aggregates, or aggrephagy, by steering ubiquitinated protein aggregates towards …
Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3BP1 and autophagy-dependent elimination of stress granules
C Yang, Z Wang, Y Kang, Q Yi, T Wang, Y Bai, Y Liu - Autophagy, 2023 - Taylor & Francis
Eukaryotic stress granules (SGs) are highly dynamic assemblies of untranslated mRNAs
and proteins that form through liquid-liquid phase separation (LLPS) under cellular stress …
and proteins that form through liquid-liquid phase separation (LLPS) under cellular stress …
TRIM16 controls assembly and degradation of protein aggregates by modulating the p62‐NRF2 axis and autophagy
Sequestration of protein aggregates in inclusion bodies and their subsequent degradation
prevents proteostasis imbalance, cytotoxicity, and proteinopathies. The underlying …
prevents proteostasis imbalance, cytotoxicity, and proteinopathies. The underlying …
[HTML][HTML] TRIM72-mediated degradation of the short form of p62/SQSTM1 rheostatically controls selective autophagy in human cells
CC Wang, H Peng, Z Wang, J Yang, RG Hu… - Military Medical …, 2022 - Springer
Autophagy is an evolutionarily conserved catabolic process that involves the sequestration
and transport of organelles, macromolecules, or invading microorganisms to lysosomes for …
and transport of organelles, macromolecules, or invading microorganisms to lysosomes for …