Role of NMDA receptors and MAP kinase in the amygdala in extinction of fear: clinical implications for exposure therapy

M Davis - European Journal of Neuroscience, 2002 - Wiley Online Library
Infusions into the amygdala (a brain area essential for excitatory fear conditioning) of either
NMDA receptor antagonists or inhibitors of the NMDA receptor‐linked mitogen activated …

Role of the amygdala in fear extinction measured with potentiated startle

M Davis, DL Walker, KM Myers - … of the New York Academy of …, 2003 - Wiley Online Library
Although much is now known about the neural basis of excitatory fear conditioning, much
less is known about the neural basis of inhibitory conditioning. One type of inhibitory …

Facilitation of conditioned fear extinction by systemic administration or intra-amygdala infusions of D-cycloserine as assessed with fear-potentiated startle in rats

DL Walker, KJ Ressler, KT Lu… - Journal of Neuroscience, 2002 - Soc Neuroscience
NMDA receptor antagonists block conditioned fear extinction when injected systemically and
also when infused directly into the amygdala. Here we evaluate the ability of d-cycloserine …

The use of cognitive enhancers in animal models of fear extinction

GB Kaplan, KA Moore - Pharmacology Biochemistry and Behavior, 2011 - Elsevier
In anxiety disorders, such as posttraumatic stress disorders and phobias, classical
conditioning pairs natural (unconditioned) fear-eliciting stimuli with contextual or discrete …

Facilitation of extinction of conditioned fear by D-cycloserine: Implications for psychotherapy

M Davis, KM Myers, KJ Ressler… - Current Directions in …, 2005 - journals.sagepub.com
Excessive fear and anxiety are characteristic of disorders such as post-traumatic stress
disorder (PTSD) and phobias and are believed to reflect abnormalities in neural systems …

Alterations of excitatory transmission in the lateral amygdala during expression and extinction of fear memory

HC Lin, SC Mao, CL Su, PW Gean - International Journal of …, 2010 - academic.oup.com
Understanding the neurophysiology of fear extinction has important implications for the
treatment of post-traumatic stress disorders. Here we report that fear conditioning resulted in …

Modulation of the extinction of fear learning

JC Myskiw, I Izquierdo, CRG Furini - Brain research bulletin, 2014 - Elsevier
We review recent work on extinction learning with emphasis on its modulation. Extinction is
the learned inhibition of responding to previously acquired tasks. Like other forms of …

The NMDA agonist D-cycloserine facilitates fear memory consolidation in humans

R Kalisch, B Holt, P Petrovic, B De Martino… - Cerebral …, 2009 - academic.oup.com
Animal research suggests that the consolidation of fear and extinction memories depends
on N-methyl D-aspartate (NMDA)-type glutamate receptors. Using a fear conditioning and …

The role of glutamate and gamma-aminobutyric acid in fear extinction: clinical implications for exposure therapy

M Davis, KM Myers - Biological psychiatry, 2002 - Elsevier
Although much is now known about the neural basis of fear acquisition, the mechanisms of
fear inhibition or suppression remain largely obscure. Fear inhibition is studied in the …

Enhancing exposure-based therapy from a translational research perspective

SG Hofmann - Behaviour research and therapy, 2007 - Elsevier
Combining an effective psychological treatment with conventional anxiolytic medication is
typically not more effective than unimodal therapy for treating anxiety disorders. However …