Towards microRNA-based therapeutics for diabetic nephropathy

ML Alvarez, JK DiStefano - Diabetologia, 2013 - Springer
There is no cure for diabetic nephropathy and the molecular mechanisms underlying
disease aetiology remain poorly understood. While current paradigms for clinical …

MicroRNA: a new generation therapeutic target in diabetic nephropathy

S Dewanjee, N Bhattacharjee - Biochemical pharmacology, 2018 - Elsevier
Diabetic nephropathy (DN) is one of the most prevalent lethal complications of diabetes that
leads to end stage renal disease. Although several clinical approaches exist to attenuate …

MicroRNAs in diabetic nephropathy: from molecular mechanisms to new therapeutic targets of treatment

A Yarahmadi, SZ Shahrokhi, Z Mostafavi-Pour… - Biochemical …, 2021 - Elsevier
Despite considerable investigation in diabetic nephropathy (DN) pathogenesis and possible
treatments, current therapies still do not provide competent prevention from disease …

The role of microRNAs in diabetic nephropathy

H Wu, L Kong, S Zhou, W Cui, F Xu… - Journal of diabetes …, 2014 - Wiley Online Library
Diabetic nephropathy (DN), as one of the chronic complications of diabetes, is the major
cause of end‐stage renal disease. However, the pathogenesis of this disease is not fully …

Deciphering the role of MicroRNAs in diabetic nephropathy: Regulatory mechanisms and molecular insights

NM Abdelmaksoud, TM Al-Noshokaty… - … -Research and Practice, 2024 - Elsevier
A serious consequence of diabetes mellitus, diabetic nephropathy (DN) which causes
gradual damage to the kidneys. Dietary changes, blood pressure control, glucose control …

MicroRNAs in diabetic nephropathy: functions, biomarkers, and therapeutic targets

M Kato, R Natarajan - Annals of the New York Academy of …, 2015 - Wiley Online Library
MicroRNAs (miRNAs) are short noncoding RNAs that regulate gene expression by
posttranscriptional and epigenetic mechanisms and thereby affect many cellular processes …

microRNAs in diabetic kidney disease

ACK Chung - microRNA: Medical Evidence: From Molecular Biology …, 2015 - Springer
Diabetes and diabetic kidney diseases have continually exerted a great burden on our
society. Although the recent advances in medical research have led to a much better …

MicroRNA circuits in transforming growth factor-β actions and diabetic nephropathy

M Kato, R Natarajan - Seminars in nephrology, 2012 - Elsevier
Diabetes is associated with significantly increased rates of kidney disease or diabetic
nephropathy (DN), a severe microvascular complication that can lead to end-stage renal …

Emerging roles for miRNAs in the development, diagnosis, and treatment of diabetic nephropathy

JK DiStefano, M Taila, ML Alvarez - Current diabetes reports, 2013 - Springer
Although the causes of diabetic nephropathy are not yet fully known, emerging evidence
suggests a role for epigenetic factors in the development of the disease. In particular …

[HTML][HTML] MicroRNA as novel biomarkers and therapeutic targets in diabetic kidney disease: an update

Q Cao, XM Chen, C Huang, CA Pollock - FASEB bioAdvances, 2019 - ncbi.nlm.nih.gov
Diabetic kidney disease (DKD) is a life‐limiting condition characterized by progressive and
irreversible loss of renal function. Currently, the estimated glomerular filtration rate (eGFR) …