Abstract β-Lactam antibiotics are one of the most relevant drug classes of antibacterial
agents worldwide. The discovery and the market of first β-lactam antibiotic (Penicillin G) is a …

β-Lactams are the most widely used class of antibiotics. Since the discovery of
benzylpenicillin in the 1920s, thousands of new penicillin derivatives and related β-lactam …

Antimicrobial resistance constitutes one of the major threats regarding pathogenic
microorganisms. Gramnegative pathogens, such as Enterobacteriaceae (specially those …

Importance of the field: β-Lactam antibiotics are among the most frequently prescribed
antibiotics used to treat bacterial infections. However, their utility is being threatened by the …

The use of successive generations of β-lactams has selected successive generations of β-
lactamases including CTX-M ESBLs, AmpC β-lactamases, and KPC carbapenamases in …

The β-lactams have a central place in the antibacterial armamentarium, but the increasing
resistance to these drugs, especially among Gram-negative bacteria, is becoming one of the …

Antibiotic resistance, and the emergence of pan-resistant clinical isolates, seriously
threatens our capability to treat bacterial diseases, including potentially deadly hospital …

The β-lactams are the most widely used antibacterial agents worldwide. These antibiotics, a
group that includes the penicillins and cephalosporins, are covalent inhibitors that target …

While β-lactam antibiotics remain among the most commonly prescribed pharmaceutical
products, their effectiveness is currently threatened by the development of bacterial …

As the incidence of Gram-negative bacterial infections for which few effective treatments
remain increases, so does the contribution of drug-hydrolyzing β-lactamase enzymes to this …