Re-evaluation of the phenotypic changes in L4 dorsal root ganglion neurons after L5 spinal nerve ligation
T Fukuoka, H Yamanaka, K Kobayashi, M Okubo… - Pain, 2012 - Elsevier
The L5 spinal nerve ligation (SNL) is a widely used animal neuropathic pain model. There
are conflicting reports regarding the extent of injury to the L4 dorsal root ganglion (DRG) …
are conflicting reports regarding the extent of injury to the L4 dorsal root ganglion (DRG) …
The role of uninjured nerve in spinal nerve ligated rats points to an improved animal model of neuropathic pain
DH Lee, S Iyengar, D Lodge - European Journal of Pain, 2003 - Elsevier
L5 and L6 spinal nerve ligation (SNL) in rats leads to behavioral signs of neuropathic pain
including mechanical allodynia. The purposes of this study were to investigate the role of the …
including mechanical allodynia. The purposes of this study were to investigate the role of the …
Pharmacological characterization and gene expression profiling of an L5/L6 spinal nerve ligation model for neuropathic pain in mice
T Kiso, T Watabiki, M Tsukamoto, M Okabe, M Kagami… - Neuroscience, 2008 - Elsevier
L5/L6 spinal nerve ligation (SNL) in rodents induces behavioral signs similar to the
symptoms of neuropathic pain in humans. L5/L6 SNL in rats has been well characterized so …
symptoms of neuropathic pain in humans. L5/L6 SNL in rats has been well characterized so …
Dorsal root section elicits signs of neuropathic pain rather than reversing them in rats with L5 spinal nerve injury
S Eschenfelder, HJ Häbler, W Jänig - Pain, 2000 - Elsevier
Mechanical allodynia-and hyperalgesia-like behavior which develops in rats after L5 spinal
nerve lesion has been suggested to be due to ectopic activity in the lesioned afferent …
nerve lesion has been suggested to be due to ectopic activity in the lesioned afferent …
Mechanical hyperalgesia after an L5 ventral rhizotomy or an L5 ganglionectomy in the rat
RN Sheth, MJ Dorsi, Y Li, BB Murinson, AJ Belzberg… - Pain, 2002 - Elsevier
An L5 spinal nerve ligation (SNL) in the rat leads to behavioral signs of mechanical
hyperalgesia. Our recent finding that an L5 dorsal root rhizotomy did not alter the …
hyperalgesia. Our recent finding that an L5 dorsal root rhizotomy did not alter the …
Contribution of primary sensory neurons and spinal glial cells to pathomechanisms of neuropathic pain
K Obata, K Noguchi - Brain and Nerve= Shinkei Kenkyu no Shinpo, 2008 - europepmc.org
Injury to the peripheral nerves often induces produces spontaneous pain, hyperalgesia
(increased responsiveness to noxious stimuli), and allodynia (painful responses to normally …
(increased responsiveness to noxious stimuli), and allodynia (painful responses to normally …
L5 spinal nerve axotomy induces sensitization of cutaneous L4 Aβ-nociceptive dorsal root ganglion neurons in the rat in vivo
L Djouhri - Neuroscience Letters, 2016 - Elsevier
Partial nerve injury often leads to peripheral neuropathic pain (PNP), a major health problem
that lacks effective drug treatment. PNP is characterized by ongoing/spontaneous pain, and …
that lacks effective drug treatment. PNP is characterized by ongoing/spontaneous pain, and …
Ligation of mouse L4 and L5 spinal nerves produces robust allodynia without major motor function deficit
GL Ye, KV Savelieva, P Vogel, KB Baker… - Behavioural brain …, 2015 - Elsevier
Spinal nerve L5/L6 ligation (SNL) in rats has become the standard for mechanistic studies of
peripheral neuropathy and screening for novel analgesics. Conventional SNL in our hybrid …
peripheral neuropathy and screening for novel analgesics. Conventional SNL in our hybrid …
Behavioral manifestations of neuropathic pain and mechanical allodynia, and changes in spinal dorsal horn neurons, following L4–L6 dorsal root constriction in rats
E Tabo, SL Jinks, JH Eisele Jr, E Carstens - Pain, 1999 - Elsevier
We investigated behavioral symptoms of neuropathic pain, and associated changes in
dorsal horn neurons, in a rat model involving loose ligation of lumbar dorsal roots. The L4 …
dorsal horn neurons, in a rat model involving loose ligation of lumbar dorsal roots. The L4 …
A partial L5 spinal nerve ligation induces a limited prolongation of mechanical allodynia in rats: an efficient model for studying mechanisms of neuropathic pain
Y Guan, F Yuan, AF Carteret, SN Raja - Neuroscience letters, 2010 - Elsevier
The relationship between pain severity and the extent of injury to a peripheral nerve remains
elusive. In this study, we compared the pain behavior resulting from partial (1/3–1/2 …
elusive. In this study, we compared the pain behavior resulting from partial (1/3–1/2 …