Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility

A Franke, T Balschun, TH Karlsen, J Sventoraityte… - Nature …, 2008 - nature.com
Inflammatory bowel disease (IBD) typically manifests as either ulcerative colitis (UC) or
Crohn's disease (CD). Systematic identification of susceptibility genes for IBD has thus far …

Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis

A Franke, T Balschun, TH Karlsen, J Hedderich… - Nature …, 2008 - nature.com
Following up on recent genome-wide association studies (GWAS) of Crohn's disease, we
investigated 50 previously reported susceptibility loci in a German sample of individuals with …

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

JZ Liu, S Van Sommeren, H Huang, SC Ng, R Alberts… - Nature …, 2015 - nature.com
Ulcerative colitis and Crohn's disease are the two main forms of inflammatory bowel disease
(IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or …

Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort

RK Weersma, PCF Stokkers, I Cleynen… - Official journal of the …, 2009 - journals.lww.com
OBJECTIVES: Inflammatory bowel diseases (IBD)—Crohn's disease (CD) and ulcerative
colitis (UC)—are chronic gastrointestinal inflammatory disorders with a complex genetic …

[PDF][PDF] Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP

A Zhernakova, EM Festen, L Franke, G Trynka… - The American Journal of …, 2008 - cell.com
The two main phenotypes of inflammatory bowel disease (IBD)—Crohn's disease (CD) and
ulcerative colitis (UC)—are chronic intestinal inflammatory disorders with a complex genetic …

Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease

MA Rivas, M Beaudoin, A Gardet, C Stevens… - Nature …, 2011 - nature.com
More than 1,000 susceptibility loci have been identified through genome-wide association
studies (GWAS) of common variants; however, the specific genes and full allelic spectrum of …

Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects

K Wang, R Baldassano, H Zhang, HQ Qu… - Human molecular …, 2010 - academic.oup.com
Inflammatory bowel disease, including Crohn's disease (CD) and ulcerative colitis (UC), and
type 1 diabetes (T1D) are autoimmune diseases that may share common susceptibility …

Genetics of inflammatory bowel disease: implications for disease pathogenesis and natural history

CW Lees, J Satsangi - Expert review of gastroenterology & …, 2009 - Taylor & Francis
Epidemiological data, detailed molecular studies and recent genome-wide association
studies strongly suggest that ulcerative colitis (UC) and Crohn's disease (CD) are related …

[PDF][PDF] A genomewide analysis provides evidence for novel linkages in inflammatory bowel disease in a large European cohort

J Hampe, S Schreiber, SH Shaw, KF Lau… - The American journal of …, 1999 - cell.com
Inflammatory bowel disease (IBD) is characterized by a chronic relapsing intestinal
inflammation, typically starting in early adulthood. IBD is subdivided into two subtypes, on …

[HTML][HTML] Deep Resequencing of GWAS Loci Identifies Rare Variants in CARD9, IL23R and RNF186 That Are Associated with Ulcerative Colitis

M Beaudoin, P Goyette, G Boucher, KS Lo… - PLoS …, 2013 - journals.plos.org
Genome-wide association studies and follow-up meta-analyses in Crohn's disease (CD)
and ulcerative colitis (UC) have recently identified 163 disease-associated loci that meet …