Emerging evidence is shedding light on a large and complex network of epigenetic
modifications at play in human stem cells. This “epigenetic landscape” governs the fine …

Two critical properties of stem cells are self-renewal and multipotency. The maintenance of
their “stemness” state and commitment to differentiation are therefore tightly controlled by …

Post-translational modifications to histone proteins and methylation of DNA comprise the
epigenome of a cell. The epigenome, which changes through development, controls access …

The precise, temporal order of gene expression during development is critical to ensure
proper lineage commitment, cell fate determination, and ultimately, organogenesis …

Increasing evidence suggests that epigenetic regulation is key to the maintenance of the
stem cell state. Chromatin is the physiological form of eukaryotic genomes and the substrate …

Stem cell-based regenerative medicine holds great promise for repair of diseased tissue.
Modern directions in the field of epigenetic research aimed to decipher the epigenetic …

Stem cells and multipotent progenitor cells face the challenge of balancing the stability and
plasticity of their developmental states. Their self-renewal requires the maintenance of a …

Epigenetic changes occur throughout life from embryonic development into adulthood. This
results in the timely expression of developmentally important genes, determining the …

Through the classic study of genetics, much has been learned about the regulation and
progression of human disease. Specifically, cancer has been defined as a disease driven by …

• Introduction• Epigenetic makeup of embryonic stem cells: keeping chromatin loose‐DNA
methylation and gene expression‐CpG methylation profiles in mouse ESCs‐CpG …