Objective We tested the ability of Notch pathway receptors Notch1 and Notch2 to regulate
stem and epithelial cell homoeostasis in mouse and human gastric antral tissue. Design …

Background & Aims Notch pathway signaling maintains gastric epithelial cell homeostasis
by regulating stem cell proliferation and differentiation. We previously identified NOTCH1 …

The Notch signaling pathway is known to regulate stem cells and epithelial cell homeostasis
in gastrointestinal tissues; however, Notch function in the corpus region of the stomach is …

The gastric epithelium is sustained by a population of stem cells that replenish the various
mature epithelial lineages throughout adulthood. Regulation of stem and progenitor cell …

The mammalian adult gastric epithelium self-renews continually through the activity of stem
cells located in the isthmus of individual gland units. Mechanisms facilitating stomach stem …

The major signaling pathways regulating gastric stem cells are unknown. Here we report
that Notch signaling is essential for homeostasis of LGR 5+ antral stem cells. Pathway …

The gastrointestinal (GI) tract epithelium is continuously replenished by actively cycling stem
and progenitor cells. These cell compartments are regulated to balance proliferation and …

The Notch signaling pathway regulates intestinal epithelial cell homeostasis, including stem
cell maintenance, progenitor cell proliferation and differentiation. Notch1 and Notch2 …

The Notch signaling pathway has become recognized as a vitally important pathway in
regulating proliferative/differentiative decisions and cell fate. To explore the involvement of …

The conserved role of Notch signaling in controlling intestinal cell fate specification and
homeostasis has been extensively studied. Nevertheless, the precise identity of the cells in …