The regenerative repair of segmental bone defect (SBD) is an urgent problem in the field of
orthopedics. Rapid induction of angiogenesis and osteoinductivity after implantation of …

Engraftment of tissue-engineered bone plays a pivotal role in the treatment of large bone
defects. However, promoting thorough vascularization in the central area of tissue …

Although vascularized tissue-engineered bone grafts (TEBG) have been generated
ectopically in several studies, the use of prevascularized TEBG for segmental bone defect …

People have been looking for tissue engineering approaches to treat large segment bone
defects as replacements of autologous bone method. Cell-seeded scaffolds are promising …

Large segmental bone defect repair remains a clinical and scientific challenge with
increasing interest focused on combining gene transfer with tissue engineering techniques …

To date, the recovery of large bone defects is a major clinical challenge despite the
availability of numerous therapeutic procedures including tissue engineering. Although …

Adequate new bone regeneration in bone defects has always been a challenge as it
requires excellent and efficient osteogenesis. Calcium phosphate (CaP) bioceramics …

Bone is a highly vascularized tissue and efficient bone regeneration requires
neovascularization, especially for critical-sized bone defects. We developed a novel hybrid …

Titanium alloy materials are commonly used in orthopedic clinical treatments. However,
conventional titanium implants usually lead to insufficient bone regeneration and integration …

Large segmental bone defect repair remains a challenge in orthopedic surgeries. The tissue
engineered bone graft will be a promising approach if vascularization of the graft is realized …