Nuclei of eukaryotic cells contain a variety of small, stable RNAs termed small nuclear
ribonucleic acids (snRNAs), most of which are involved in the modification or maturation of …

In the 20 years since the discovery that many eukaryotic genes are interrupted by non-
coding intervening sequences, or introns, biologists have learnt a tremendous amount about …

A ubiquitous feature of eukaryotes is the presence of intervening sequences that interrupt
the coding regions of genes. Nuclear pre-mRNA splicing is the process by which these …

Pre-mRNA splicing in eukaryotes requires joining together the nucleotides of the various
mRNA-coding regions (exons) after recognizing them from the normally vastly superior …

Significant progress has been made over the last year in our understanding of the roles that
RNA-binding proteins play in pre-mRNA splicing, the components of the spliceosome and …

Intervening sequences are removed from nuclear pre-mRNAs in a well-defined multi-step
pathway. Small nuclear ribonucleoprotein particles (snRNPs) and numerous protein factors …

The primary transcripts of most nuclear protein-coding genes of eu-karyotes are interrupted
by intervening sequences (or introns) that are removed from the pre-mRNA in a process …

Proteins have been implicated in an expanding variety of functions during pre-mRNA
splicing. Molecular cloning has identified genes encoding spliceosomal proteins that …

Many pre-mRNA splicing factors are phosphorylated in vivo, but the role of this modification
has been unclear. Recent observations suggest that phosphorylation modulates protein …

Eukaryotic cells contain small, highly abundant, nuclear-localized non-coding RNAs
[snRNAs (small nuclear RNAs)] which play important roles in splicing of introns from primary …