In the 20 years since the discovery that many eukaryotic genes are interrupted by non- coding intervening sequences, or introns, biologists have learnt a tremendous amount about …
A ubiquitous feature of eukaryotes is the presence of intervening sequences that interrupt the coding regions of genes. Nuclear pre-mRNA splicing is the process by which these …
E Buratti, FE Baralle - Molecular and cellular biology, 2004 - Taylor & Francis
Pre-mRNA splicing in eukaryotes requires joining together the nucleotides of the various mRNA-coding regions (exons) after recognizing them from the normally vastly superior …
DC Rio - Current Opinion in Cell Biology, 1992 - Elsevier
Significant progress has been made over the last year in our understanding of the roles that RNA-binding proteins play in pre-mRNA splicing, the components of the spliceosome and …
A Krämer - Annual review of biochemistry, 1996 - annualreviews.org
Intervening sequences are removed from nuclear pre-mRNAs in a well-defined multi-step pathway. Small nuclear ribonucleoprotein particles (snRNPs) and numerous protein factors …
AI Lamond, RG Landes Company, A Krämer - Pre-mRNA processing, 1995 - Springer
The primary transcripts of most nuclear protein-coding genes of eu-karyotes are interrupted by intervening sequences (or introns) that are removed from the pre-mRNA in a process …
CL Will, R Lührmann - Current opinion in cell biology, 1997 - Elsevier
Proteins have been implicated in an expanding variety of functions during pre-mRNA splicing. Molecular cloning has identified genes encoding spliceosomal proteins that …
Many pre-mRNA splicing factors are phosphorylated in vivo, but the role of this modification has been unclear. Recent observations suggest that phosphorylation modulates protein …
S Valadkhan, LS Gunawardane - Essays in biochemistry, 2013 - portlandpress.com
Eukaryotic cells contain small, highly abundant, nuclear-localized non-coding RNAs [snRNAs (small nuclear RNAs)] which play important roles in splicing of introns from primary …