Medical records-based chronic kidney disease phenotype for clinical care and “big data” observational and genetic studies

N Shang, A Khan, F Polubriaginof, F Zanoni… - Npj Digital …, 2021 - nature.com
Abstract Chronic Kidney Disease (CKD) represents a slowly progressive disorder that is
typically silent until late stages, but early intervention can significantly delay its progression …

[HTML][HTML] Unbiased kidney-centric molecular categorization of chronic kidney disease as a step towards precision medicine

A Reznichenko, V Nair, S Eddy, D Fermin, M Tomilo… - Kidney International, 2024 - Elsevier
Current classification of chronic kidney disease (CKD) into stages using indirect systemic
measures (estimated glomerular filtration rate (eGFR) and albuminuria) is agnostic to the …

Genome-wide association studies of CKD and related traits

A Tin, A Köttgen - Clinical Journal of the American Society of …, 2020 - journals.lww.com
The past few years have seen major advances in genome-wide association studies (GWAS)
of CKD and kidney function–related traits in several areas: increases in sample size from> …

[HTML][HTML] Development and validation of an electronic phenotyping algorithm for chronic kidney disease

GN Nadkarni, O Gottesman, JG Linneman… - AMIA Annual …, 2014 - ncbi.nlm.nih.gov
Twenty-six million Americans are estimated to have chronic kidney disease (CKD) with
increased risk for cardiovascular disease and end stage renal disease. CKD is frequently …

[HTML][HTML] Machine learning, the kidney, and genotype–phenotype analysis

RSG Sealfon, LH Mariani, M Kretzler… - Kidney international, 2020 - Elsevier
With biomedical research transitioning into data-rich science, machine learning provides a
powerful toolkit for extracting knowledge from large-scale biological data sets. The …

Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies

AP Morris, TH Le, H Wu, A Akbarov… - Nature …, 2019 - nature.com
Chronic kidney disease (CKD) affects~ 10% of the global population, with considerable
ethnic differences in prevalence and aetiology. We assemble genome-wide association …

Integrated multi-omics approaches to improve classification of chronic kidney disease

S Eddy, LH Mariani, M Kretzler - Nature Reviews Nephrology, 2020 - nature.com
Chronic kidney diseases (CKDs) are currently classified according to their clinical features,
associated comorbidities and pattern of injury on biopsy. Even within a given classification …

The CKDGen Consortium: ten years of insights into the genetic basis of kidney function

A Köttgen, C Pattaro - Kidney international, 2020 - kidney-international.org
With increasing incidence and a prev-alence of> 10% among adults worldwide, chronic
kidney disease (CKD) represents a major public health issue. 1 CKD can lead to metabolic …

[HTML][HTML] Genetics in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) controversies conference

A Köttgen, E Cornec-Le Gall, J Halbritter, K Kiryluk… - Kidney international, 2022 - Elsevier
Numerous genes for monogenic kidney diseases with classical patterns of inheritance, as
well as genes for complex kidney diseases that manifest in combination with environmental …

A catalog of genetic loci associated with kidney function from analyses of a million individuals

M Wuttke, Y Li, M Li, KB Sieber, MF Feitosa, M Gorski… - Nature …, 2019 - nature.com
Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic
complications. Through trans-ancestry meta-analysis of genome-wide association studies of …