The vacuolar proton-translocating ATPase (V-ATPase) is a transmembrane multi-protein
complex fundamental in maintaining a normal intracellular pH. In the tumoral contest, its role …

Background Glioblastoma (GBM) is a lethal brain tumor characterized by the glioma stem
cell (GSC) niche. The V-ATPase proton pump has been described as a crucial factor in …

Abstract The vacuolar H+ ATPase (V-ATPase) is a proton pump responsible for acidification
of cellular microenvironments, an activity exploited by tumors to survive, proliferate and …

Abstract Background The V-ATPase proton pump controls acidification of intra and extra-
cellular milieu in both physiological and pathological conditions. We previously showed that …

The vacuolar ATPases are ATP-dependent proton pumps whose functions include the
acidification of intracellular compartments and the extrusion of protons through the cell …

Abstract Vacuolar ATPase (V‐ATPase) is an ATP‐dependent H+‐transporter that pumps
protons across intracellular and plasma membranes. It consists of a large multi‐subunit …

Abstract Vacuolar-type H+-ATPase (V-ATPase) is a crucial proton pump that plays an
essential role in maintaining intracellular pH homeostasis and a variety of physiological …

Background Glioblastoma multiforme (GBM) is a very aggressive form of brain cancer that
carries with it a tragically poor prognosis. As with many other forms of cancer, the …

Cancer cells show a metabolic shift that makes them overproduce protons; this has the
potential to disturb the cellular acidbase homeostasis. However, these cells show …

Abstract Development of resistance to platinum compounds significantly hinders successful
ovarian cancer (OVCA) treatment. In tumor cells, dysregulated pH gradient across cell …