Immunometabolic signatures predict risk of progression to sepsis in COVID-19

AS Herrera-Van Oostdam, JE Castañeda-Delgado… - PLoS …, 2021 - journals.plos.org
Viral sepsis has been proposed as an accurate term to describe all multisystemic
dysregulations and clinical findings in severe and critically ill COVID-19 patients. The …

[PDF][PDF] Plasma metabolomic and lipidomic alterations associated with COVID-19

D Wu, T Shu, X Yang, JX Song, M Zhang… - National Science …, 2020 - academic.oup.com
The pandemic of the coronavirus disease 2019 (COVID-19) has become a global public
health crisis. The symptoms of COVID-19 range from mild to severe, but the physiological …

Taxonomical and functional changes in COVID‐19 faecal microbiome could be related to SARS‐CoV‐2 faecal load

L Grenga, O Pible, G Miotello, K Culotta… - Environmental …, 2022 - Wiley Online Library
Since the beginning of the pandemic caused by the severe acute respiratory syndrome
coronavirus 2 (SARS‐CoV‐2) the gastrointestinal (GI) tract has emerged as an important …

The specific metabolome profiling of patients infected by SARS-COV-2 supports the key role of tryptophan-nicotinamide pathway and cytosine metabolism

H Blasco, C Bessy, L Plantier, A Lefevre, E Piver… - Scientific reports, 2020 - nature.com
The biological mechanisms involved in SARS-CoV-2 infection are only partially understood.
Thus we explored the plasma metabolome of patients infected with SARS-CoV-2 to search …

16S rRNA gene sequencing of rectal swab in patients affected by COVID-19

A Mazzarelli, ML Giancola, A Farina, L Marchioni… - PLoS …, 2021 - journals.plos.org
COronaVIrus Disease-2019 (COVID-19) is a pandemic respiratory infection caused by a
new betacoronavirus, the Severe Acute Respiratory Syndrome-CoronaVirus-2 (SARS-CoV …

Longitudinal metabolomics reveals ornithine cycle dysregulation correlates with inflammation and coagulation in COVID-19 severe patients

T Li, N Ning, B Li, D Luo, E Qin, W Yu, J Wang… - Frontiers in …, 2021 - frontiersin.org
COVID-19 is a severe disease in humans, as highlighted by the current global pandemic.
Several studies about the metabolome of COVID-19 patients have revealed metabolic …

Prolonged impairment of short-chain fatty acid and L-isoleucine biosynthesis in gut microbiome in patients with COVID-19

F Zhang, Y Wan, T Zuo, YK Yeoh, Q Liu, L Zhang… - Gastroenterology, 2022 - Elsevier
Background and Aims Coronavirus disease 2019 (COVID-19) caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with altered gut …

Amino acid metabolism is significantly altered at the time of admission in hospital for severe COVID-19 patients: findings from longitudinal targeted metabolomics …

L Ansone, M Briviba, I Silamikelis… - Microbiology …, 2021 - Am Soc Microbiol
The heterogeneity in severity and outcome of COVID-19 cases points out the urgent need for
early molecular characterization of patients followed by risk-stratified care. The main …

Targeted metabolomics identifies high performing diagnostic and prognostic biomarkers for COVID-19

Y López-Hernández, J Monárrez-Espino… - Scientific Reports, 2021 - nature.com
Research exploring the development and outcome of COVID-19 infections has led to the
need to find better diagnostic and prognostic biomarkers. This cross-sectional study used …

Immunomodulatory fecal metabolites are associated with mortality in COVID-19 patients with respiratory failure

MR Stutz, NP Dylla, SD Pearson… - Nature …, 2022 - nature.com
Respiratory failure and mortality from COVID-19 result from virus-and inflammation-induced
lung tissue damage. The intestinal microbiome and associated metabolites are implicated in …