A new paradigm in respiratory hygiene: increasing the cohesivity of airway secretions to improve cough interaction and reduce aerosol dispersion

G Zayas, J Dimitry, A Zayas, D O'Brien, M King - BMC Pulmonary Medicine, 2005 - Springer
Background Infectious respiratory diseases are transmitted to non-infected subjects when an
infected person expels pathogenic microorganisms to the surrounding environment when …

A new paradigm in respiratory hygiene: modulating respiratory secretions to contain cough bioaerosol without affecting mucus clearance

G Zayas, JC Valle, M Alonso, H Alfaro, D Vega… - BMC Pulmonary …, 2007 - Springer
Background Several strategies and devices have been designed to protect health care
providers from acquiring transmissible respiratory diseases while providing care. In …

Roles of mucus adhesion and cohesion in cough clearance

B Button, HP Goodell, E Atieh… - Proceedings of the …, 2018 - National Acad Sciences
Clearance of intrapulmonary mucus by the high-velocity airflow generated by cough is the
major rescue clearance mechanism in subjects with mucoobstructive diseases and failed …

Mucus hypersecretion and mucus clearance in cough

WM Foster - Cough: causes, mechanisms and therapy, 2003 - Wiley Online Library
The tracheobronchial airways of the human lung are largely covered by a liquid lining of
mucus. The mucus is a viscoelastic secretion that serves as a barrier for entrapment of …

Models using native tracheobronchial mucus in the context of pulmonary drug delivery research: composition, structure and barrier properties

BC Huck, X Murgia, S Frisch, M Hittinger… - Advanced Drug Delivery …, 2022 - Elsevier
Mucus covers all wet epithelia and acts as a protective barrier. In the airways of the lungs,
the viscoelastic mucus meshwork entraps and clears inhaled materials and efficiently …

Airway mucus in pulmonary diseases: Muco-adhesive and muco-penetrating particles to overcome the airway mucus barriers

R Pangeni, T Meng, S Poudel, D Sharma… - International journal of …, 2023 - Elsevier
Airway mucus is a complex viscoelastic gel that provides a defensive physical barrier and
shields the airway epithelium by trapping inhaled foreign pathogens and facilitating their …

Mucous gel transport in a simulated cough machine: effects of longitudinal grooves representing spacings between arrays of cilia

M Agarwal, M King, JB Shukla - Biorheology, 1994 - content.iospress.com
Under some conditions, such as inhalation injury, an array of longitudinal channels without
cilia may be formed on the epithelial surface, affecting mucus transport in the lung during …

What it takes for a cough to expel mucus from the airway

BF Dickey - Proceedings of the National Academy of …, 2018 - National Acad Sciences
Cough is one of the most common symptoms for seeking medical care (1, 2). If cough is
going to cause that much trouble, it better be worth it, and the clinical evidence is that indeed …

The role of mucus in cough research

BK Rubin - Lung, 2010 - Springer
Cough is a defense mechanism for promoting airway hygiene when mucociliary clearance is
ineffective due to increased mucus secretion, inflammation, infection, or ciliary dysfunction …

Strategies for measuring airway mucus and mucins

KR Atanasova, LR Reznikov - Respiratory Research, 2019 - Springer
Mucus secretion and mucociliary transport are essential defense mechanisms of the
airways. Deviations in mucus composition and secretion can impede mucociliary transport …