Objectives To explore the association between rate of physical health deterioration,
operationalized as rising multimorbidity overtime, and longitudinal decline in cognitive …

Background Multimorbidity is associated with greater disability and accelerated declines in
physical functioning over time in older adults. However, less is known about its effect on …

OBJECTIVES: Although cognitive impairment and depressive symptoms are associated with
functional decline, it is not understood how these risk factors act together to affect the risk of …

Background Multimorbidity (multiple co-occurring chronic conditions) may be an important
contributor to disability and poor health-related quality of life. The functional consequences …

Introduction Co-occurrence with other chronic diseases may influence the progression of
dementia, especially in case of multiple chronic diseases. We aimed to verify whether …

OBJECTIVES: To simultaneously examine the influence of functional disability on the
development of cognitive impairment and the influence of cognitive status on the …

Objectives To determine the association between multiple chronic conditions and risk of
incident mild cognitive impairment (MCI) and dementia. Design Prospective cohort study …

Background Inter-relationships between multimorbidity and geriatric syndromes are poorly
understood. This study assesses heterogeneity in joint trajectories of somatic disease …

Background. The number of diseases and physical functioning difficulties tend to increase
with age. The aim of this study was to examine the trajectories of physical functioning across …

Objective To investigate the temporal ordering of cognitive and functional declines
separately in older adults with or without Alzheimer's disease (AD). Design and Setting A …