Wilson Disease: Copper-Mediated Cuproptosis, Iron-Related Ferroptosis, and Clinical Highlights, with Comprehensive and Critical Analysis Update

R Teschke, A Eickhoff - International Journal of Molecular Sciences, 2024 - mdpi.com
Wilson disease is a genetic disorder of the liver characterized by excess accumulation of
copper, which is found ubiquitously on earth and normally enters the human body in small …

Current and emerging issues in Wilson's disease

EA Roberts, ML Schilsky - New England Journal of Medicine, 2023 - Mass Medical Soc
Current and Emerging Issues in Wilson’s Disease | New England Journal of Medicine Skip to
main content The New England Journal of Medicine homepage Advanced Search SEARCH …

Update on Wilson disease

A Aggarwal, M Bhatt - International Review of Neurobiology, 2013 - Elsevier
Wilson disease (WD) is an inherited disorder of chronic copper toxicosis characterized by
excessive copper deposition in the body, primarily in the liver and the brain. It is a …

Wilson's disease: a comprehensive review of the molecular mechanisms

F Wu, J Wang, C Pu, L Qiao, C Jiang - International journal of molecular …, 2015 - mdpi.com
Wilson's disease (WD), also known as hepatolenticular degeneration, is an autosomal
recessive inherited disorder resulting from abnormal copper metabolism. Reduced copper …

Effects of iron and copper overload on the human liver: an ultrastructural study

D Fanni, V Fanos, C Gerosa, M Piras… - Current Medicinal …, 2014 - ingentaconnect.com
Iron and copper ions play important roles in many physiological functions of our body, even
though the exact mechanisms regulating their absorption, distribution and excretion are not …

Other organ involvement and clinical aspects of Wilson disease

K Dzieżyc, T Litwin, A Członkowska - Handbook of clinical neurology, 2017 - Elsevier
Wilson disease (WD) is a rare disorder of copper metabolism that presents mainly with
hepatic and neuropsychiatric features. Copper accumulates not only in the liver and brain …

Wilson's disease: an update on the diagnostic workup and management

B Kasztelan-Szczerbinska, H Cichoz-Lach - Journal of clinical medicine, 2021 - mdpi.com
Wilson's disease (WD) is a rare autosomal recessive disorder of hepatocellular copper
deposition. The diagnostic approach to patients with WD may be challenging and is based …

cellular copper toxicity: a critical appraisal of fenton-chemistry-based oxidative stress in Wilson disease

H Zischka, J Lichtmannegger - Wilson Disease, 2019 - Elsevier
The redox activity of copper is of vital importance for biochemical and bioenergetic cellular
homeostasis. However, cellular copper overload leads to cell death. Wilson disease patients …

Wilson's disease: A 2017 update

A Poujois, F Woimant - Clinics and research in hepatology and …, 2018 - Elsevier
Wilson's disease (WD) is characterised by a deleterious accumulation of copper in the liver
and brain. It is one of those rare genetic disorders that benefits from effective and lifelong …

[HTML][HTML] Wilson disease

KH Weiss, M Schilsky - 2016 - europepmc.org
Wilson disease is a disorder of copper metabolism that, when untreated, can present with
hepatic, neurologic, or psychiatric disturbances–or a combination of these–in individuals …