Leishmaniasis is a disease complex caused by 20 species of protozoan parasites belonging
to the genus Leishmania. In humans, it has two main clinical forms, visceral leishmaniasis …

Chronic tegumentary leishmaniasis is characterized by a scarcity of parasites in lesions and
a heightened inflammatory response. Deregulated and hyperactive inflammation contributes …

Leishmaniasis is endemic to the tropical and subtropical regions of the world and is
transmitted by the bite of an infected sand fly. The multifaceted interactions between …

Cutaneous leishmaniasis (CL) is caused by parasitic infection of dermal macrophages
resulting in intense immune‐mediated tissue inflammation and skin ulceration. The severity …

Macrophages are the major host cells for Leishmania parasites, and determine the fate of
infection by either limiting or allowing growth of the parasites, resulting in development or …

Infection by protozoan parasites of the genus Leishmania results in the development of
leishmaniasis, an increasingly prevalent group of diseases affecting over 12 million people …

Studies in the recent years have advanced the knowledge of how host and parasite factors
contribute to the pathogenesis of human tegumentary leishmaniasis. Polymorphism within …

Parasites of the genus Leishmania are classified by genetic, biological, and immunological
criteria. Different species trigger diverse clinical manifestations that are the result of …

Leishmania are protozoan parasites that predominantly reside in myeloid cells within their
mammalian hosts. Monocytes and macrophages play a central role in the pathogenesis of …

In humans, infection with Leishmania manifests into a spectrum of diseases. The
manifestation of the diseases depend on the resultant evasion of the parasite to immune …