Synthesis and biological evaluation of PSMA-targeting paclitaxel conjugates

AE Machulkin, DA Skvortsov, YA Ivanenkov… - Bioorganic & Medicinal …, 2019 - Elsevier
Prostate cancer (PC) is the second most commonly occurring cancer in men. Conventional
chemotherapy has wide variety of disadvantages such as high systemic toxicity and low …

Prostate-specific membrane antigen targeted therapy of prostate cancer using a DUPA–paclitaxel conjugate

Q Lv, J Yang, R Zhang, Z Yang, Z Yang… - Molecular …, 2018 - ACS Publications
Prostate cancer (PCa) is the most prevalent cancer among men in the United States and
remains the second-leading cause of cancer mortality in men. Paclitaxel (PTX) is the first line …

Design and synthesis of a PSMA inhibitor-doxorubicin conjugate for targeted prostate cancer therapy

S Jayaprakash, X Wang, WD Heston… - …, 2006 - pure.johnshopkins.edu
Prostate-specific membrane antigen (PSMA) provides an attractive target for the
development of targeted chemotherapeutics for prostate cancer. We have designed and …

Old drug, new delivery strategy: MMAE repackaged

H Lahnif, T Grus, EA Salvanou, E Deligianni… - International Journal of …, 2023 - mdpi.com
Targeting therapy is a concept that has gained significant importance in recent years,
especially in oncology. The severe dose-limiting side effects of chemotherapy necessitate …

Advances in non-radioactive PSMA-targeted small molecule-drug conjugates in the treatment of prostate cancer

M Chen, L Cai, Y Xiang, L Zhong, J Shi - Bioorganic Chemistry, 2023 - Elsevier
Most patients with advanced prostate cancer (PCa) will develop metastatic castration-
resistant prostate cancer (mCRPC) after androgen deprivation therapy, at this time the tumor …

PSMA-targeted small-molecule docetaxel conjugate: Synthesis and preclinical evaluation

AE Machulkin, AA Uspenskaya, NY Zyk… - European Journal of …, 2022 - Elsevier
Prostate cancer is one of the most commonly diagnosed men's cancers and remains one of
the leading causes of cancer death. The development of approaches to the treatment of this …

[HTML][HTML] PSMA-targeted combination brusatol and docetaxel nanotherapeutics for the treatment of prostate cancer

TA Adekiya, T Hudson, O Bakare, EE Ameyaw… - Biomedicine & …, 2024 - Elsevier
Active targeting to cancer involves exploiting specific interactions between receptors on the
surface of cancer cells and targeting moieties conjugated to the surface of vectors such that …

Synthesis of Prostate-Specific Membrane Antigen-Targeted Bimodal Conjugates of Cytotoxic Agents and Antiandrogens and Their Comparative Assessment with …

NY Zyk, AS Garanina, EA Plotnikova, AP Ber… - International Journal of …, 2023 - mdpi.com
Prostate cancer is the second most common cancer among men. We designed and
synthesized new ligands targeting prostate-specific membrane antigen and suitable for …

Synthesis and Preclinical Evaluation of Urea-Based Prostate-Specific Membrane Antigen-Targeted Conjugates Labeled with 177Lu

AE Machulkin, SA Petrov, V Bodenko… - ACS pharmacology & …, 2024 - ACS Publications
177Lu-labeled small-molecule prostate-specific membrane antigen (PSMA) targeted tracers
are therapeutic agents for metastatic castration-resistant prostate cancer. Optimizing …

Small molecule-based prodrug targeting prostate specific membrane antigen for the treatment of prostate cancer

X Wang, A Shirke, E Walker, R Sun, G Ramamurthy… - Cancers, 2021 - mdpi.com
Simple Summary Currently, there is no effective treatment that can cure metastatic prostate
cancer. Various pros-tate specific membrane antigen (PSMA)-targeted radioimaging and …