Angiogenesis is a crucial component of bone remodeling under both normal and
pathophysiological conditions. Among the various mediators that regulate the angiogenic …

Background Angiopoietin (Ang)-1 and Ang-2, and their shared receptor Tie2, are expressed
in rheumatoid arthritis (RA) synovial tissue, but the cellular targets of Ang signalling and the …

Breast cancer causes morbidity and mortality among women worldwide, despite much
research illuminating the genetic basis of this disease. Anti-angiogenesis therapies have …

Background Synovial angiogenesis is a component of rheumatoid pannus and considered
to be an important early step in the pathogenesis of rheumatoid arthritis (RA). Objectives The …

Atherosclerosis and cardiovascular diseases (CVD) are increasingly recognised
complications of rheumatoid arthritis (RA). Angiopoietin 2 (Ang-2) levels have been …

Angiopoietin-like 2 (ANGPTL2) is a proinflammatory protein belonging to the angiopoietin-
like family. ANGPTL2 is secreted and detected in the systemic circulation. Serum levels of …

Background: Osteoarthritis (OA) is a complex disorder characterized by the breakdown of
articular cartilage and underlying bone and is largely attributed to genetic risk factors. Single …

AIM: Although the ANGPTL6 (angiopoietin-like 6) gene product is now known to be involved
in the regulation of fat mass and insulin sensitivity in mice, its physiological functions in …

OBJECTIVE: Angiopoietin-I (Ang-1) and Ang-2 are ligands for the receptor tyrosine kinase,
Tie-2. Ang-1, a Tie-2 agonist, may have a vascular stabilizing role in angiogenesis, while …

The article is devoted to the assessment of the relationship between the serum
concentrations of angiopoietin-like proteins of types 3 and 4 (ANGPTL 3 and 4) and the …