Background Mutations in LRRK2 gene represent the most common known genetic cause of
Parkinson's disease (PD). Methodology/Principal Findings We used metabolomic profiling to …

To identify novel susceptibility loci for Crohn disease (CD), we undertook a genome-wide
association study with more than 300,000 SNPs characterized in 547 patients and 928 …

Mutations in LRRK2 cause familial Parkinson's disease and common variants increase
disease risk. LRRK2 kinase activity and cellular localization are tightly regulated by …

LRRK2 is one of the most important genetic contributors to Parkinson's disease (PD). Point
mutations in this gene cause an autosomal dominant form of PD, but to date no cellular …

As part of a broader collaborative network of exome sequencing studies, we developed a
jointly called data set of 5,685 Ashkenazi Jewish exomes. We make publicly available a …

The presence of α-synuclein Lewy body pathology is used to distinguish Parkinson's
disease from parkinsonism, for which a broader spectrum of neuropathologies, including tau …

Background: LRRK2 variants have been demonstrated to have distinct distributions in
different populations. However, researchers have thus far chosen to focus on relatively few …

The goal of genetic association studies is to identify common (> 5%) risk factors in complex
disease traits. Herein we describe the first replicable 'functional'risk allele for Parkinson's …

Leucine-rich repeat kinase 2 (LRRK2) is a large, ubiquitous protein of unknown function.
Mutations in the gene encoding LRRK2 have been linked to familial and sporadic …

LRRK2, a Parkinson's disease associated gene, is highly expressed in microglia in addition
to neurons; however, its function in microglia has not been evaluated. Using Lrrk2 …