We present a genome-wide association study of ileal Crohn disease and two independent
replication studies that identify several new regions of association to Crohn disease …

Genome-wide association studies (GWASs) have identified hundreds of loci associated with
Crohn's disease (CD). However, as with all complex diseases, robust identification of the …

Crohn's disease (CD) and celiac disease (CelD) are chronic intestinal inflammatory
diseases, involving genetic and environmental factors in their pathogenesis. The two …

The era of genome-wide association (GWA) scanning has shed new light on the genetic
basis of common disease and nowhere is this better illustrated than Crohn's disease (CD) …

Inflammatory bowel diseases involve the dynamic interaction of host genetics, the
microbiome and inflammatory responses. Here we found lower expression of NLRP12 …

Advances in genetics have shed light on the molecular basis of Crohn's disease (CD)
predisposition and pathogenesis, via linkage disequilibrium analysis to genome-wide …

OBJECTIVES: Inflammatory bowel diseases (IBD)—Crohn's disease (CD) and ulcerative
colitis (UC)—are chronic gastrointestinal inflammatory disorders with a complex genetic …

OBJECTIVES Crohn's disease (CD) is a chronic inflammatory disease of the gut associated
with allelic variants of CARD15 and HLA-DRB1 genes. We investigated the prevalence and …

Interactions among the gut microbiome, dysregulated immune responses, and genetic
factors contribute to the pathogenesis of inflammatory bowel disease (IBD). Nlrx1−/− mice …

Pattern recognition receptors are essential mediators of host defense and inflammation in
the gastrointestinal system. Recent data have revealed that toll-like receptors and nucleotide …