Background An emerging body of literature has indicated that broad, transdiagnostic
dimensions of psychopathology are associated with alterations in brain structure across the …

Objective A general psychopathology (p) factor captures shared variation across mental
disorders. Structural neural alterations have been associated with the p factor concurrently …

Objective: High comorbidity among psychiatric disorders suggests that they may share
underlying neurobiological deficits. Abnormalities in cortical thickness and volume have …

General psychopathology and cognition are likely to have a bidirectional influence on each
other. Yet, the relationship between brain structure, psychopathology, and cognition remains …

Childhood is an important time for the manifestation of psychopathology. Psychopathology is
characterized by considerable comorbidity which is mirrored in the underlying neural …

Background Internalizing and externalizing psychopathology typically present in early
childhood and can have negative implications on general functioning and quality of life …

Psychopathology is rooted in neurodevelopment. However, clinical and biological
heterogeneity, together with a focus on case-control approaches, have made it difficult to link …

Psychiatric disorders are highly heritable and polygenic, and many have their peak onset in
late childhood and adolescence, a period of tremendous changes. Although the …

Background Integrating multiple neuroimaging modalities to identify clusters of individuals
and then associating these clusters with psychopathology is a promising approach for …

Background Many studies of brain-behavior relationships rely on univariate approaches
where each variable of interest is tested independently, which does not allow for the …