INTRODUCTION The cerebral cortex is responsible for higher-order functions in the nervous
system and has undergone substantial expansion in size in primates. The development of …

During mammalian development, differences in chromatin state coincide with cellular
differentiation and reflect changes in the gene regulatory landscape. In the developing brain …

We analyzed> 700,000 single-nucleus RNA sequencing profiles from 106 donors during
prenatal and postnatal developmental stages and identified lineage-specific programs that …

Recent advances in single-cell transcriptomics have illuminated the diverse neuronal and
glial cell types within the human brain. However, the regulatory programs governing cell …

Abstract Analysis of chromatin accessibility can reveal transcriptional regulatory sequences,
but heterogeneity of primary tissues poses a significant challenge in mapping the precise …

The cellular complexity of the human brain is established via dynamic changes in gene
expression throughout development that is mediated, in part, by the spatiotemporal activity …

The mammalian cerebral cortex has an unparalleled diversity of cell types, which are
generated during development through a series of temporally orchestrated events that are …

Joint profiling of chromatin accessibility and gene expression from the same single cell
provides critical information about cell types in a tissue and cell states during a dynamic …

Three-dimensional physical interactions within chromosomes dynamically regulate gene
expression in a tissue-specific manner,,. However, the 3D organization of chromosomes …

Systematic analyses of spatiotemporal gene expression trajectories during organogenesis
have been challenging because diverse cell types at different stages of maturation and …