LRRK2 and human disease: a complicated question or a question of complexes?
Leucine-rich repeat kinase 2 (LRRK2) is linked to various diseases, including Parkinson's
disease, cancer, and leprosy. Data from LRRK2 knockout mice has highlighted a possible …
disease, cancer, and leprosy. Data from LRRK2 knockout mice has highlighted a possible …
Leucine-rich repeat kinase 2 at a glance
Leucine-rich repeat kinase 2 (LRRK2) is a multidomain scaffolding protein with dual
guanosine triphosphatase (GTPase) and kinase enzymatic activities, providing this protein …
guanosine triphosphatase (GTPase) and kinase enzymatic activities, providing this protein …
LRRK2 regulation of immune-pathways and inflammatory disease
RL Wallings, MG Tansey - Biochemical Society Transactions, 2019 - portlandpress.com
Mutations in the leucine-rich-repeat kinase 2 (LRRK2) gene are associated with familial and
sporadic cases of Parkinson's disease but are also found in immune-related disorders such …
sporadic cases of Parkinson's disease but are also found in immune-related disorders such …
LRRK2 and the immune system
NL Dzamko - Leucine-Rich Repeat Kinase 2 (LRRK2), 2017 - Springer
Polymorphisms in leucine-rich repeat kinase 2 (LRRK2) have been linked to familial
Parkinson's disease, increased risk of sporadic Parkinson's disease, increased risk of …
Parkinson's disease, increased risk of sporadic Parkinson's disease, increased risk of …
[HTML][HTML] Function and dysfunction of leucine-rich repeat kinase 2 (LRRK2): Parkinson's disease and beyond
JR Bae, BD Lee - BMB reports, 2015 - ncbi.nlm.nih.gov
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial
Parkinson's disease (PD). As such, functions and dysfunctions of LRRK2 in PD have been …
Parkinson's disease (PD). As such, functions and dysfunctions of LRRK2 in PD have been …
[HTML][HTML] LRRK2 as a target for modulating immune system responses
Abstract Mutations in the Leucine-Rich Repeat Kinase 2 (LRRK2) gene are associated with
familial and sporadic cases of Parkinson's disease (PD) but are also found in patients with …
familial and sporadic cases of Parkinson's disease (PD) but are also found in patients with …
Lrrk2 alleles modulate inflammation during microbial infection of mice in a sex-dependent manner
B Shutinoski, M Hakimi, IE Harmsen, M Lunn… - Science translational …, 2019 - science.org
Variants in the leucine-rich repeat kinase-2 (LRRK2) gene are associated with Parkinson's
disease, leprosy, and Crohn's disease, three disorders with inflammation as an important …
disease, leprosy, and Crohn's disease, three disorders with inflammation as an important …
Disruption of LRRK2 in Zebrafish leads to hyperactivity and weakened antibacterial response
D Sheng, K See, X Hu, D Yu, Y Wang, Q Liu, F Li… - Biochemical and …, 2018 - Elsevier
As a protein with complex domain structure and roles in kinase, GTPase and scaffolding,
LRRK2 is believed to be an important orchestration node leading to several cascades of …
LRRK2 is believed to be an important orchestration node leading to several cascades of …
[HTML][HTML] A LRRK2 GTP binding inhibitor, 68, reduces LPS-induced signaling events and TNF-α release in human lymphoblasts
T Li, B Ning, L Kong, B Dai, X He, JM Thomas, A Sawa… - Cells, 2021 - mdpi.com
Mutations in the leucine-rich repeat kinase-2 (LRRK2) gene cause autosomal-dominant
Parkinson's disease (PD) and contribute to sporadic PD. Common genetic variation in …
Parkinson's disease (PD) and contribute to sporadic PD. Common genetic variation in …
The neurobiology of LRRK2 and its role in the pathogenesis of Parkinson's disease
HJ Rideout, L Stefanis - Neurochemical research, 2014 - Springer
Leucine-rich repeat kinase 2 (LRRK2) is a large, widely expressed protein of largely
unknown function. Mutations in the gene encoding LRRK2 have been linked to multiple …
unknown function. Mutations in the gene encoding LRRK2 have been linked to multiple …