Complex interactions: the immunogenetics of human leukocyte antigen and killer cell immunoglobulin-like receptors

PJ Norman, P Parham - Seminars in hematology, 2005 - Elsevier
The killer cell immunoglobulin-like receptors (KIR) for human leukocyte antigen (HLA)
modulate innate and adaptive immunity by controlling effector cells. HLA and KIR are …

Immunogenomics of killer cell immunoglobulin-like receptor (KIR) and HLA class I: coevolution and consequences for human health

NR Pollock, GF Harrison, PJ Norman - The Journal of Allergy and Clinical …, 2022 - Elsevier
Interactions of killer cell immunoglobin-like receptors (KIR) with human leukocyte antigens
(HLA) class I regulate effector functions of key cytotoxic cells of innate and adaptive …

The killer immunoglobulin-like receptor gene cluster: tuning the genome for defense

AA Bashirova, MP Martin, DW McVicar… - Annu. Rev. Genomics …, 2006 - annualreviews.org
Killer immunoglobulin-like receptors (KIRs) are molecules expressed on the surface of
natural killer (NK) cells, which play an important role in innate immunity. KIR recognition of …

Speed and selection in the evolution of killer‐cell immunoglobulin‐like receptors

J Martinez‐Borra, SI Khakoo - International journal of …, 2008 - Wiley Online Library
The killer‐cell immunoglobulin‐like receptors (KIR) form a diverse family of receptors that
control the functions of natural killer cells. Sequencing of KIR from primates has revealed the …

The Impact of Variation at the KIR Gene Cluster on Human Disease

M Carrington, MP Martin - Immunobiology of Natural Killer Cell Receptors, 2006 - Springer
Leukocyte behavior is controlled by a balance of inhibitory and stimulatory signals
generated on ligand binding to a complex set of receptors located on the cell surface. The …

[HTML][HTML] Hanging in the balance

AP Williams, AR Bateman… - Molecular …, 2005 - triggered.edina.clockss.org
The killer cell immunoglobulin-like receptors (KIR) are a recently discovered family of
activating and inhibitory receptors that control natural killer (NK) cell function. KIR exist as a …

Structure/function of human killer cell immunoglobulin‐like receptors: lessons from polymorphisms, evolution, crystal structures and mutations

KS Campbell, AK Purdy - Immunology, 2011 - Wiley Online Library
Stimulation or tolerance of natural killer (NK) cells is achieved through a cross‐talk of signals
derived from cell surface activating and inhibitory receptors. Killer cell immunoglobulin‐like …

Overview of the killer cell immunoglobulin-like receptor system

R Rajalingam - Immunogenetics: Methods and Applications in Clinical …, 2012 - Springer
Natural killer (NK) cells are more than simple killers and have been implicated in control and
clearance of malignant and virally infected cells, regulation of adaptive immune responses …

Innate receptors with high specificity for HLA class I–peptide complexes

MJW Sim, P Brennan, KL Wahl, J Lu… - Science …, 2023 - science.org
Genetic studies associate killer cell immunoglobulin-like receptors (KIRs) and their HLA
class I ligands with a variety of human diseases. The basis for these associations and the …

Killer cell immunoglobulin-like receptors influence the innate and adaptive immune responses

R Rajalingam - Iranian Journal of Immunology, 2007 - iji.sums.ac.ir
Natural killer (NK) cells are a subset of lymphocytes which play a crucial role in early innate
immune response against infection and tumor transformation. Furthermore, they secrete …