Uncovering Hidden Mechanisms of Different Prescriptions Treatment for Osteoporosis via Novel Bioinformatics Model and Experiment Validation

Y Liu, Q Liu, C Yin, Y Li, J Wu, Q Chen, H Yu… - Frontiers in cell and …, 2022 - frontiersin.org
Osteoporosis (OP) is a systemic disease susceptible to fracture due to the decline of bone
mineral density and bone mass, the destruction of bone tissue microstructure, and increased …

Investigation of the underlying mechanism of Zhibai Dihuang Pill in treating osteoporosis by using network pharmacology and molecular dynamics simulation

Y Feng, L Zhang, C Zhao, N Li… - Endocrine, Metabolic & …, 2023 - ingentaconnect.com
Background: With society aging, the rising prevalence of osteoporosis (OP) has enormous
social and economic implications. At present, the Zhibai Dihuang pill has been clinically …

Analysis of Shared Mechanisms and Chinese Herbal Medicines Between Osteoporosis and Type 2 Diabetes

H Yang, F Luo, Z Xiong - Pharmacognosy Magazine, 2024 - journals.sagepub.com
Background Osteoporosis (OP) and type 2 diabetes (T2D) are commonly encountered
metabolic disorders in clinical practice, but the comorbidity mechanism has not been …

Exploring the mechanism of action Xianlingubao Prescription in the treatment of osteoporosis by network pharmacology

N Zhu, J Hou - Computational Biology and Chemistry, 2020 - Elsevier
In this study, the network pharmacology analysis method was used to explore the bioactive
components and targets of Xianlinggubao (XLGB) and further elucidate its potential …

[HTML][HTML] Integrative analysis of bone-formation associated genes and immune cell infiltration in osteoporosis, and the prediction of active ingredients in targeted …

K Wang, P Dong, H Guo - Digital Chinese Medicine, 2024 - Elsevier
Objective To explore the differential expression and mechanisms of bone formation-related
genes in osteoporosis (OP) leveraging bioinformatics and machine learning methodologies …

[HTML][HTML] Network pharmacology combined with bioinformatics to investigate the mechanism of Xianlinggubao capsule in the treatment of osteoporosis

Y Li, R Li, Z Zeng, S Li, S Liao, W Ma, C Zhou, D Xu - Phytomedicine Plus, 2021 - Elsevier
Background Xianlinggubao capsule (XLGB), a traditional Chinese medicine (TCM)
prescription, has been widely applied to treat osteoporosis (OP) in China. However, its …

Network pharmacology-based strategy to investigate pharmacological mechanism of Liuwei Dihuang Pill against postmenopausal osteoporosis

Q Wang, P Huang, C Xia, D Fu - Medicine, 2022 - journals.lww.com
Postmenopausal osteoporosis (PMOP) has became 1 of most prevalent bone disorders with
aging population. Liuwei Dihuang (LWDH) Pill, a classical kidney-tonifying prescription, is …

Study on complications of osteoporosis based on network pharmacology

Z Song, H Zhang, Y Jiang, R Zhao, X Pei, H Ning… - Frontiers in …, 2022 - frontiersin.org
Osteoporosis is a serious threat to human life. Guben Zenggu Granule is an empirical
prescription for clinical treatment of osteoporosis. MC3T3-E1 cells are mouse osteogenic …

To Explore the Rule and Mechanism of Traditional Chinese Medicine in the Treatment of Postmenopausal Osteoporosis Based on Data Mining, Network …

H Zeng, K Huang, Y Chai, H Liu, Y Li… - Natural Product …, 2024 - journals.sagepub.com
Postmenopausal osteoporosis (PMOP) is an important part of primary osteoporosis, and the
current clinical treatment program for PMOP is easily limited by side effects and adverse …

Using network pharmacology and molecular docking verification to explore the mechanism of ursolic acid in the treatment of osteoporosis

B Yang, Q Zhu, X Wang, J Mao, S Zhou - Medicine, 2022 - journals.lww.com
Whether ursolic acid is an effective drug in treatment of osteoporosis (OP) and how it exhibit
activity effect on OP is unclear. To investigated the potential molecular mechanism of ursolic …