Protein kinase C (PKC) has been proposed as a primary cellular mediator of ischemic
preconditioning. However, the role of PKC in eliciting cardioprotection remains controversial …

Brief periods of ischemia that precede sustained ischemia can markedly reduce infarct size
(IS), a phenomenon that is known as ischemic preconditioning (IP). Several investigators …

Although protein kinase C (PKC) plays a key role in ischemic preconditioning (IPC), the
actual mechanism of that protection is unknown. We recently found that protection from IPC …

Background. Ischemic stress and other protein kinase C (PKC)–linked receptor stimuli can
induce rapid cardiac protection against ischemia-reperfusion injury. We and others have …

The hypothesis that brief ischemia (preconditioning) protects the isolated heart from
prolonged global ischemia was tested. Isovolumic rat hearts were preconditioned with either …

Protein kinase C (PKC) has been implicated in the preconditioning-induced cardiac
protection in ischemic/reperfused myocardium. We studied the effect of PKC inhibition with …

Protein kinase C (PKC) has been implicated in the cardioprotective effects of ischemic
preconditioning in rabbits, but whether it plays a role in rats is unknown. We tested this …

Objectives: We have recently proposed that chloride (Cl−) channels contribute to ischemic
preconditioning (IPC) in the myocardium. To further evaluate this hypothesis, we …

Since the discovery of ischemic preconditioning (IPC) 26 years ago, numerous studies
attempted to determine the mechanism of this powerful form of cardioprotection. One of the …

BACKGROUND Ischemic preconditioning slows ATP depletion and ultrastructural damage
during the final episode of ischemia. To define the influence of creatine phosphate (CP) and …